The 5-HT7 receptor is a member of the GPCR superfamily of cell surface receptors and is activated by the neurotransmitter serotonin (5-hydroxytryptamine, 5-HT). [5] .

Dec 25, 2024 · HTR7 (5-Hydroxytryptamine Receptor 7) is a Protein Coding gene. Diseases associated with HTR7 include Migraine With Or Without Aura 1 and Alcohol Dependence. Among its related pathways are Class A/1 (Rhodopsin-like receptors) and Monoamine GPCRs.

Feb 10, 2025 · 本研究旨在探索5-HT7R和CCR5在细菌性脑膜炎中的相互作用机制，揭示血清素信号如何通过调控CCR5的表达来缓解感染引发的过度免疫反应和认知功能损伤，为神经免疫调控提供新的理论基础和治疗靶点。 本论文由Zhenfang Gao、Yang Gao等研究人员共同完成，作者来自北京基础医学研究所（Beijing Institute of Basic Medical Sciences）和首都医科大学脑疾病研究所（Beijing Institute of Brain Disorders, Capital Medical University）。

Jun 20, 2022 · In this review, we describe the signaling pathways and cellular mechanisms implicated in the activation of the 5-HT 7 R; also, we analyze different mechanisms of neurodegeneration and the potential therapeutic implications of pharmacological interventions for 5-HT 7 R signaling.

May 16, 2018 · Preclinical data link the 5-HT 7 R to a variety of central nervous system processes including the regulation of circadian rhythms, mood, cognition, pain processing, and mechanisms of addiction. 5-HT 7 R blockade has antidepressant effects and may ameliorate cognitive deficits associated with schizophrenia. 5-HT 7 R has been recently shown to mod...

Results: Fluoxetine, a selective serotonin reuptake inhibitor, or the agonist of serotonin receptor 5-HT 7 R, protects mice from meningitis by inhibiting CCR5-mediated excessive immune response and tissue damage.

Dec 31, 2019 · Serotonin effects are mediated through its interaction with 5-HT receptors (5-HTRs), a superfamily with a repertoire of at least fourteen well-characterized members. 5-HT 7 receptors are the last 5-HTR member to be identified, with well-defined functions in the nervous, gastrointestinal, and vascular systems.

Aug 23, 2018 · In an electroencephalogram (EEG) test, 1g increased total non-rapid eye movement (NREM) sleep time and decreased total rapid eye movement (REM) sleep time. Though many studies have been published about therapeutic potentials of selective 5-HT₇R ligands, there have been few biased ligands of 5-HT₇R.

Aug 1, 2015 · Here, we demonstrate that expression of serotonin receptor 5-HT7 (5-HT7R) as well as its downstream effector Cdc42 is upregulated in dendritic cells upon maturation. Although dendritic cell maturation was independent of 5-HT7R, receptor stimulation affected dendritic cell morphology through Cdc42-mediated signaling.

Serotonin 5-HT 7 receptor (5-HT 7 R), one of the most recently discovered members of the serotonergic system, has become a promising target in the search for central nervous system disorders.