4-Nitroquinoline N -oxide is a quinoline derivative widely used in chemical research and development. [1] 4-Nitroquinoline N -oxide has been used as a model compound to study its carcinogenic effects. [2] [3] Skin and lung tumor initiator under experimental conditions. Choose from one of the most recent versions: Don't see the Right Version?

The 4NQO carcinogen model has the advantage that it can be used with transgenic mice with genetic modification in specific tissue types to investigate their role in driving cancer progression. Herein, we describe the basic approach for administering 4NQO to mice to induce OSCC and methods for assessing the tissue and disease progression.

The 4NQO molecule forms DNA adducts, causes substitutions of adenosine for guanosine, and evokes intracellular oxidative stress, resulting in genetic mutations and DNA strand breaks.

4-Nitroquinoline-1-Oxide is a quinoline derivative with potent tumorigenic activity. 4-nitroquinoline-1-oxide (4-NQO) potentially induces DNA damage by either binding directly to DNA and disrupting replication or through the generation of reactive oxygen species (ROS). 4-NQO is also metabolized to form other mutagenic compounds, such as 8-hydrox...

4-Nitroquinoline 1-oxide (4NQO) is used as a positive control in various genotoxicity assays because of its known mutagenic and carcinogenic properties. The chemical is converted into 4-hydroxyaminoquinoline 1-oxide and gives rise to three main DNA ...

Jan 1, 2021 · Many laboratories have used the chemical carcinogen 4-nitroquinoline-1-oxide (4NQO) to investigate OSCC formation. The importance of the 4NQO mouse model is that it mimics the stepwise progression observed in OSCC patients.

4-Nitroquinoline 1-oxide (4-NQO) is a highly carcinogenic chemical that induces mutations in bacteria, fungi, and animals through the formation of bulky purine adducts. 4-NQO has been used as a mutagen for genetic screens and in both the study of DNA damage and DNA repair.

Animal models that mimic histological and biological processes of human oral carcinogenesis may help to improve the identification of OPMD at-risk of progression into oral squamous cell carcinoma and to develop preventive strategies for the entire field of cancerization.

Objective: Based on a critical review of published studies, we aimed to develop a good practice guide for using 4-nitroquinoline-1-oxide (4NQO) as an inducer of oral carcinogenesis in Wistar rats. Design: A systematic search was performed on Medline Ovid, PubMed, Embase, Web of Science, and Scopus databases.

Aug 1, 2022 · 4-nitroquinoline-1-oxide (4NQO) is a mutagenic substance capable of generating changes in DNA that mimic tobacco-induced molecular events and can be used for experimental oral carcinogenesis development [15].