
蛋白翻译后修饰——泛素化 - 知乎 - 知乎专栏
3.1蛋白酶体与26s蛋白酶体. 蛋白酶体的大小约为20s,呈桶状结构,能够将几乎所有的蛋白降解成7~9个氨基酸长度的肽链。蛋白酶体降解蛋白质的活性中心位于桶状结构的中心,与细胞中其它部分隔离。
蛋白酶体 - 百度百科
蛋白酶体广泛分布于细胞质和细胞核中,26s蛋白酶体是一种分子量为2000的多亚基复合物,约有50种蛋白质亚基组成。 具有多种蛋白水解酶活性,并且具有泛素依赖性。
Structure and Function of the 26S Proteasome - PubMed
Jun 20, 2018 · As the endpoint for the ubiquitin-proteasome system, the 26S proteasome is the principal proteolytic machine responsible for regulated protein degradation in eukaryotic cells. The proteasome's cellular functions range from general protein homeostasis and stress response to the control of vital proce …
The life cycle of the 26S proteasome: from birth, through regulation ...
Jul 22, 2016 · The 26S proteasome is a large, ∼2.5 MDa, multi-catalytic ATP-dependent protease complex that serves as the degrading arm of the ubiquitin system, which is the major pathway for regulated ...
Mechanisms and regulation of substrate degradation by the 26S
Oct 3, 2024 · This paper provides exciting insights into the various conformational states of the substrate-engaged 26S proteasome and its allosteric regulation by USP14 to coordinate the various steps of ...
摘要 26s蛋白酶体是真核细胞内负责蛋白质降解的主要分子机器, 通过特异性降解目的 蛋白质, 几乎参与了生物体的绝大多数生命活动. 26S蛋白酶体在 ...
施一公院士再发表PNAS:蛋白酶体新研究 - 搜狐
Mar 2, 2016 · 26s蛋白酶体是真核细胞内负责蛋白质降解的主要分 子机器,通过特异性降解目的蛋白,几乎参与了生物体的绝大多数生命活动。26s蛋白酶体在结构上可分为19s调节颗粒和20s核心颗粒两部分。
Proteasome 26S (Untagged, Human)
We sell human untagged Proteasome 26S purified by fractionation from human red blood cells. The 26S exhibits the highest activity and is soluble and homogenous.
Nature突破丨北大毛有东组解析人源蛋白酶体26S七种中间态高分 …
Nature突破丨北大毛有东组解析人源蛋白酶体26S七种中间态高分辨构象,冷冻电镜进入全原子动力学分析新时代 BioArt生物艺术 科研等 2 个话题下的优秀答主
蛋白酶体 26S 亚基,ATPase 2(PSMC2)基因 | MCE
26s 蛋白酶体是一种多催化蛋白酶复合物,具有由 2 个复合物、20s 核心和 19s 调节剂组成的高度有序结构。 20s 核心由 28 个不同亚基的 4 个环组成; 2 个环由 7 个α亚基组成,2 个环由 7 个β亚基组成。