14-3-3 proteins are a family of conserved regulatory molecules that are expressed in all eukaryotic cells. 14-3-3 proteins have the ability to bind a multitude of functionally diverse signaling proteins, including kinases, phosphatases, and transmembrane receptors. More than 200 signaling proteins have been reported as 14-3-3 ligands.

The 14-3-3 proteins are a family of conserved regulatory molecules expressed in all eukaryotic cells. A striking feature of the 14-3-3 proteins is their ability to bind a multitude of functionally diverse signaling proteins, including kinases, phosphatases, and transmembrane receptors.

14-3-3 proteins are a family of conserved regulatory adaptor molecules which are expressed in all eukaryotic cells. These proteins participate in a variety of intracellular processes by recognizing specific phosphorylation motifs and interacting with hundreds of target proteins.

14-3-3-Proteine sind regulatorische Proteine, die in der Zelle als Liganden verschiedener Signalproteine (u.a. Phosphatasen und Kinasen) dienen. Sie führen über einen Isotypenwechsel zum Zelltod von Neuronen, was besonders bei der Labordiagnostik der Creutzfeldt-Jakob-Krankheit (CJK) relevant ist.

Because many 14-3-3 interactions are phosphorylation-dependent, 14-3-3 has been tightly integrated into the core phospho-regulatory pathways that are crucial for normal growth and development and that often become dysregulated in human disease states such as cancer.

2023年3月16日 · 14-3-3 proteins, which act as homo- and heterodimers, bind phosphomotifs in disordered regions of their clients through a conserved amphipathic groove. Despite a seemingly simple mode of client binding, 14-3-3s modulate the function of …

2025年1月31日 · Plotegher N, Kumar D, Tessari I, et al. The chaperone-like protein 14-3-3η interacts with human α-synuclein aggregation intermediates rerouting the amyloidogenic pathway and reducing α-synuclein cellular toxicity. Hum Mol Genet. 2014;23(21):5615-5629.

2005年4月1日 · 14-3-3 is a highly conserved acidic protein family, composed of seven isoforms in mammals. 14-3-3 protein can interact with over 200 target proteins by phosphoserine-dependent and...

14-3-3 protein dimerization enables scaffolding, which either stabilizes the oligomeric state of the target protein or anchors two different proteins near each other. A paradigmatic example of such a mechanism is the activation of plant plasma membrane H +-ATPase (Ottmann et al., 2007a).

2024年1月26日 · The 14–3-3ε protein is involved in various physiological processes, including signal transduction, cell proliferation, apoptosis, autophagy, cell cycle regulation, repolarization of cardiac action, cardiac development, intracellular electrolyte homeostasis, neurodevelopment, and innate immunity.

2021年4月1日 · 14-3-3 proteins are highly conserved in species ranging from yeast to mammals and regulate numerous signalling pathways via direct interactions with proteins carrying phosphorylated 14-3-3–binding motifs. Recent studies have shown that 14-3-3 proteins can also play a role in viral infections.

2002年3月7日 · As a result, 14-3-3s are involved in a vast array of processes such as the response to stress, cell-cycle control, and apoptosis, serving as adapters, activators, and repressors. There are currently 133 full-length sequences available in GenBank for this highly conserved protein family.

2020年10月2日 · 14-3-3 domain is an essential part of 14-3-3 proteins, a ubiquitous class of regulatory, phosphoserine/threonine-binding proteins found in all eukaryotic cells, including yeast, protozoa and mammalian cells. 14-3-3 proteins play important roles in many biological processes that are regulated by phosphorylation, including cell cycle regulation ...

2018年6月18日 · In this review, we discuss emerging 14-3-3 regulatory mechanisms with a focus on post-translational regulation of 14-3-3 and dynamic protein–protein interactions that illustrate...

14-3-3s are a group of relatively low molecular weight, acidic, dimeric, protein(s) conserved from single-celled yeast to multicellular vertebrates including humans. Despite lacking catalytic activity, these proteins have been shown to be involved in multiple cellular processes.

2003年12月1日 · Processes that are relevant to cancer biology and that are regulated by 14-3-3 protein interactions include cell-cycle progression, apoptosis and mitogenic signalling. 14-3-3 proteins bind to...

2024年12月1日 · 14–3–3 s inhibit neuronal apoptosis by suppressing Bad and Bax proteins translocation. 14–3–3 s regulates the breakdown processes of tau, Aβ and α-Syn proteins. Downregulation of 14–3–3 s linked to excitotoxicity-induced neurodegeneration. It is important to maintain adequate amounts of 14–3–3 s for neuroprotection.

2022年1月1日 · 14-3-3 proteins form constitutive α-helical dimers having clamp-like shapes and featuring the so-called amphipathic grooves (AGs) for the phosphopeptide binding, one per subunit. The crystal structure of 14-3-3 dimers has been known since as early as 1995 (Liu et al., 1995; Xiao et al., 1995).

2025年2月4日 · 14–3–3 proteins play a crucial role in the regulation of protein–protein interactions, impacting various cellular processes and disease mechanisms. Recent advancements have led to the development of stabilizers that enhance the binding of 14–3–3 proteins to clients, presenting promising therapeutic potentials.

1 天前 · Fun Half link: https://youtube.com/live/gTh61mJ1EZ4 Sam and Emma speak with Jeet Heer, national affairs correspondent for The Nation to round up the week in ...