
14-3-3 protein - Wikipedia
14-3-3 proteins are a family of conserved regulatory molecules that are expressed in all eukaryotic cells. 14-3-3 proteins have the ability to bind a multitude of functionally diverse signaling …
14-3-3 proteins: structure, function, and regulation - PubMed
The 14-3-3 proteins are a family of conserved regulatory molecules expressed in all eukaryotic cells. A striking feature of the 14-3-3 proteins is their ability to bind a multitude of functionally …
14-3-3 Proteins Are on the Crossroads of Cancer, Aging, and Age …
14-3-3 proteins are a family of conserved regulatory adaptor molecules which are expressed in all eukaryotic cells. These proteins participate in a variety of intracellular processes by …
14-3-3-Protein - DocCheck Flexikon
14-3-3-Proteine sind regulatorische Proteine, die in der Zelle als Liganden verschiedener Signalproteine (u.a. Phosphatasen und Kinasen) dienen. Sie führen über einen …
The 14-3-3 proteins: integrators of diverse signaling cues that …
Because many 14-3-3 interactions are phosphorylation-dependent, 14-3-3 has been tightly integrated into the core phospho-regulatory pathways that are crucial for normal growth and …
A central chaperone-like role for 14-3-3 proteins in human cells
2023年3月16日 · 14-3-3 proteins, which act as homo- and heterodimers, bind phosphomotifs in disordered regions of their clients through a conserved amphipathic groove. Despite a …
What Is the Function and Relevance of 14-3-3 Proteins in …
2025年1月31日 · Plotegher N, Kumar D, Tessari I, et al. The chaperone-like protein 14-3-3η interacts with human α-synuclein aggregation intermediates rerouting the amyloidogenic …
14-3-3 proteins—an update | Cell Research - Nature
2005年4月1日 · 14-3-3 is a highly conserved acidic protein family, composed of seven isoforms in mammals. 14-3-3 protein can interact with over 200 target proteins by phosphoserine …
Structural insights into the functional roles of 14-3-3 proteins
14-3-3 protein dimerization enables scaffolding, which either stabilizes the oligomeric state of the target protein or anchors two different proteins near each other. A paradigmatic example of …
14–3-3ε: a protein with complex physiology function but …
2024年1月26日 · The 14–3-3ε protein is involved in various physiological processes, including signal transduction, cell proliferation, apoptosis, autophagy, cell cycle regulation, repolarization …
The role of 14‐3‐3 proteins in cell signalling pathways and virus ...
2021年4月1日 · 14-3-3 proteins are highly conserved in species ranging from yeast to mammals and regulate numerous signalling pathways via direct interactions with proteins carrying …
The 14-3-3s | Genome Biology | Full Text - BioMed Central
2002年3月7日 · As a result, 14-3-3s are involved in a vast array of processes such as the response to stress, cell-cycle control, and apoptosis, serving as adapters, activators, and …
CDD Conserved Protein Domain Family: 14-3-3 - National Center …
2020年10月2日 · 14-3-3 domain is an essential part of 14-3-3 proteins, a ubiquitous class of regulatory, phosphoserine/threonine-binding proteins found in all eukaryotic cells, including …
The dynamic and stress-adaptive signaling hub of 14-3-3 ... - Nature
2018年6月18日 · In this review, we discuss emerging 14-3-3 regulatory mechanisms with a focus on post-translational regulation of 14-3-3 and dynamic protein–protein interactions that illustrate...
14-3-3 Protein - an overview | ScienceDirect Topics
14-3-3s are a group of relatively low molecular weight, acidic, dimeric, protein(s) conserved from single-celled yeast to multicellular vertebrates including humans. Despite lacking catalytic …
The 14-3-3 cancer connection - Nature Reviews Cancer
2003年12月1日 · Processes that are relevant to cancer biology and that are regulated by 14-3-3 protein interactions include cell-cycle progression, apoptosis and mitogenic signalling. 14-3-3 …
14–3-3 protein and its isoforms: A common diagnostic marker for ...
2024年12月1日 · 14–3–3 s inhibit neuronal apoptosis by suppressing Bad and Bax proteins translocation. 14–3–3 s regulates the breakdown processes of tau, Aβ and α-Syn proteins. …
Recent advances in structural studies of 14-3-3 protein complexes
2022年1月1日 · 14-3-3 proteins form constitutive α-helical dimers having clamp-like shapes and featuring the so-called amphipathic grooves (AGs) for the phosphopeptide binding, one per …
Recent Developments in 14–3–3 Stabilizers for Regulating Protein ...
2025年2月4日 · 14–3–3 proteins play a crucial role in the regulation of protein–protein interactions, impacting various cellular processes and disease mechanisms. Recent …
Casual Friday! w/ Jeet Heer | MR Live - 3/14/25 - YouTube
1 天前 · Fun Half link: https://youtube.com/live/gTh61mJ1EZ4 Sam and Emma speak with Jeet Heer, national affairs correspondent for The Nation to round up the week in ...