14-3-3 proteins are a family of conserved regulatory molecules that are expressed in all eukaryotic cells. 14-3-3 proteins have the ability to bind a multitude of functionally diverse signaling …

The 14-3-3 proteins are a family of conserved regulatory molecules expressed in all eukaryotic cells. A striking feature of the 14-3-3 proteins is their ability to bind a multitude of functionally …

14-3-3 proteins are a family of conserved regulatory adaptor molecules which are expressed in all eukaryotic cells. These proteins participate in a variety of intracellular processes by …

14-3-3-Proteine sind regulatorische Proteine, die in der Zelle als Liganden verschiedener Signalproteine (u.a. Phosphatasen und Kinasen) dienen. Sie führen über einen …

Because many 14-3-3 interactions are phosphorylation-dependent, 14-3-3 has been tightly integrated into the core phospho-regulatory pathways that are crucial for normal growth and …

2023年3月16日 · 14-3-3 proteins, which act as homo- and heterodimers, bind phosphomotifs in disordered regions of their clients through a conserved amphipathic groove. Despite a …

2025年1月31日 · Plotegher N, Kumar D, Tessari I, et al. The chaperone-like protein 14-3-3η interacts with human α-synuclein aggregation intermediates rerouting the amyloidogenic …

2005年4月1日 · 14-3-3 is a highly conserved acidic protein family, composed of seven isoforms in mammals. 14-3-3 protein can interact with over 200 target proteins by phosphoserine …

14-3-3 protein dimerization enables scaffolding, which either stabilizes the oligomeric state of the target protein or anchors two different proteins near each other. A paradigmatic example of …

2024年1月26日 · The 14–3-3ε protein is involved in various physiological processes, including signal transduction, cell proliferation, apoptosis, autophagy, cell cycle regulation, repolarization …

2021年4月1日 · 14-3-3 proteins are highly conserved in species ranging from yeast to mammals and regulate numerous signalling pathways via direct interactions with proteins carrying …

2002年3月7日 · As a result, 14-3-3s are involved in a vast array of processes such as the response to stress, cell-cycle control, and apoptosis, serving as adapters, activators, and …

2020年10月2日 · 14-3-3 domain is an essential part of 14-3-3 proteins, a ubiquitous class of regulatory, phosphoserine/threonine-binding proteins found in all eukaryotic cells, including …

2018年6月18日 · In this review, we discuss emerging 14-3-3 regulatory mechanisms with a focus on post-translational regulation of 14-3-3 and dynamic protein–protein interactions that illustrate...

14-3-3s are a group of relatively low molecular weight, acidic, dimeric, protein(s) conserved from single-celled yeast to multicellular vertebrates including humans. Despite lacking catalytic …

2003年12月1日 · Processes that are relevant to cancer biology and that are regulated by 14-3-3 protein interactions include cell-cycle progression, apoptosis and mitogenic signalling. 14-3-3 …

2024年12月1日 · 14–3–3 s inhibit neuronal apoptosis by suppressing Bad and Bax proteins translocation. 14–3–3 s regulates the breakdown processes of tau, Aβ and α-Syn proteins. …

2022年1月1日 · 14-3-3 proteins form constitutive α-helical dimers having clamp-like shapes and featuring the so-called amphipathic grooves (AGs) for the phosphopeptide binding, one per …

2025年2月4日 · 14–3–3 proteins play a crucial role in the regulation of protein–protein interactions, impacting various cellular processes and disease mechanisms. Recent …

1 天前 · Fun Half link: https://youtube.com/live/gTh61mJ1EZ4 Sam and Emma speak with Jeet Heer, national affairs correspondent for The Nation to round up the week in ...