RNA silencing or RNA interference refers to a family of gene silencing effects by which gene expression is negatively regulated by non-coding RNAs such as microRNAs. RNA silencing may also be defined as sequence-specific regulation of gene expression triggered by double-stranded RNA (dsRNA). [1]

Double-stranded RNA-mediated interference (RNAi) is a simple and rapid method of silencing gene expression in a range of organisms. The silencing of a gene is a consequence of degradation of RNA into short RNAs that activate ribonucleases to target homologous mRNA.

2004年9月15日 · There are at least three RNA silencing pathways for silencing specific genes in plants. In these pathways, silencing signals can be amplified and transmitted between cells, and may even be...

RNA silencing is an evolutionarily conserved mechanism in eukaryotes. It is induced by double-stranded RNA (dsRNA) or hairpin structured RNA (hpRNA), involving common factors including Dicer or Dicer-like (DCL) and Argonaute (AGO) family proteins [1 - 3].

RNA silencing is a type of gene regulation that, in plants, serves as an antiviral defense. RNA silencing is based on targeting specific sequences of RNA and degrading them. RNA silencing occurs in a broad range of eukaryotic organisms, including plants, fungi, and animals.

2017年11月9日 · RNA interference or Post-Transcriptional Gene Silencing is a conserved biological response to double-stranded RNA that mediates resistance to both endogenous parasitic and exogenous pathogenic nucleic acids, and …

RNA silencing (or RNA interference, RNAi) is a conserved mechanism for regulating gene expression in eukaryotes. The discovery of natural trans-kingdom RNAi indicated that small RNAs act as signaling molecules and enable communication between organisms in different kingdoms.

2002年1月17日 · RNA silencing is a sequence-specific RNA degradation mechanism that occurs in a broad range of eukaryotic organisms including fungi (quelling), animals (RNA interference [RNAi]), and plants (post-transcriptional gene silencing).

On the molecular level, RNA interference is mediated by a family of ribonucleoprotein complexes called RNA-induced silencing complexes (RISCs), which can be programmed to target virtually any nucleic acid sequence for silencing.

2005年7月29日 · We study the RNA silencing pathway using concise differential equation models with mass action kinetics. There is strong evidence that there is a common core pathway of RNA silencing present in all organisms capable of RNA silencing.