N-acetyltransferase 2 (arylamine N-acetyltransferase), also known as NAT2, is an enzyme which in humans is encoded by the NAT2 gene. [5] This gene encodes a type of N-acetyltransferase. The NAT2 isozyme functions to both activate and deactivate arylamine and …

2024年12月25日 · NAT2 (N-Acetyltransferase 2) is a Protein Coding gene. Diseases associated with NAT2 include Acetylation, Slow and Tuberculosis. Among its related pathways are Metapathway biotransformation Phase I and II and Paracetamol ADME.

2020年1月8日 · NAT2 is one of only 2 N-acetyltransferase genes in humans; the other, NAT1, shows little variation between individuals, whereas NAT2 is known to have over 23 variants. N-acetyltransferases are enzymes acting primarily in the liver to detoxify a large number of chemicals, including caffeine and several prescribed drugs.

2024年12月28日 · The NAT2 gene (NAT2 stands for N-acetyltransferase 2) is a protein-coding gene located on chromosome 8p22. Several transcript variants have been found for this gene, which code for different isoforms.

2025年1月4日 · NAT2 slow acetylator genotype plays an important role in determining the risk of developing prostate cancer in Japanese men and is also associated with more clinically advanced and pathologically aggressive disease. NAT2 polymorphisms are associated with lung cancer

Arylamine N -acetyltransferase type 2 (NAT2) is a highly polymorphic phase 2 metabolic enzyme that conjugates hydrazine derivatives and aromatic amine drugs with acetyl-groups.

NAT2. NAT2 is in the colon, liver and small intestine. The enzyme N-acetyltransferase 2 acts primarily in the liver to detox several chemicals, caffeine, toxins, and prescription drugs. Depending on all your other NAT2 SNPs you can determine/alter your …

Two NAT genes (NAT1 and NAT2) have been characterized in humans, which differ in gene structure, extent of genetic variation, pattern of developmental and tissue expression [6 – 8].

Arylamine N -acetyltransferase 2 (NAT2) is a phase II xenobiotic-metabolising enzyme with medical relevance, responsible for the biotransformation of several therapeutic drugs, environmental and diet compounds [1 – 5].

N-acetyltransferase 2 (NAT2) enzyme is a Phase II drug-metabolizing enzyme that metabolizes different compounds. Genetic variations in NAT2 can influence the enzyme’s activity and potentially lead to the development of certain diseases. This study ...