Macrophage-stimulating protein (MSP), also known as hepatocyte growth factor-like protein (HLP, HGFL, or HGFLP), is a protein that in humans is encoded by the MST1 (macrophage-stimulating 1) gene. [5] [6] [7]

Mammalian Mst1 and Mst2 kinases play essential role in the regulation of cellular redox state. See text for details.

2013年8月28日 · The serine/threonine protein kinases Mst1 and Mst2, mammalian homologs of the Hippo kinase from Drosophila, play the central roles in the Hippo pathway controlling the cell proliferation, differentiation, and apoptosis during development.

2024年12月25日 · MST1 (Macrophage Stimulating 1) is a Protein Coding gene. Diseases associated with MST1 include Immunodeficiency 14 and Cholangitis, Primary Sclerosing . Among its related pathways are Hippo-Merlin signaling dysregulation and MSP-RON Signaling .

MST1 or MST2 overexpression was also found to consistently induce apoptosis; moreover, apoptosis activated the endogenous MST1/MST2 kinases, 4–9 responses suggestive of a physiologic role for these kinases in effecting apoptosis.

2025年1月4日 · Title: Mst1-mediated phosphorylation of Nur77 improves the endometrial receptivity in human and mice. Macrophage-stimulating protein is decreased in severe preeclampsia and regulates the biological behavior of HTR-8/SVneo trophoblast cells.

Mst1 promotes mitochondrial dysfunction and apoptosis in oxidative stress-induced rheumatoid arthritis synoviocytes. Macrophage stimulating 1-induced inflammation response promotes aortic aneurysm formation through triggering endothelial cells death and activating the NF-kappaB signaling pathway.

Mammalian STE20-like kinase-1 (Mst1) is a generally expressed apoptosis-promoting kinase and a key bridgebuilder of apoptotic signaling in the etiology of tissue injury.

2003年5月5日 · In this study, we show that Mst1 is a prominent myelin basic protein kinase activated by proapoptotic stimuli in cardiac myocytes and that Mst1 causes cardiac myocyte apoptosis in vitro in a kinase activity–dependent manner.

MST kinases are emerging as key signaling molecules that influence cell proliferation, organ size, cell migration, and cell polarity. Here we review the regulation and function of these kinases in normal physiology and pathologies, including cancer, endothelial malformations, and …