Fluid supplementation can promote the elimination of colchicine through the kidneys. Early PE combined with CVVHDF may improve the prognosis. ECLS can be recommended as a vital supportive treatment for fatal colchicine poisoning. Both G-CSF and TPO can attenuate the severity and shorten the duration of neutropenia and thrombocytopenia.

2023年5月29日 · Treatment of colchicine poisoning should start with gastric lavage and measures to prevent shock. Otherwise, treatment is symptomatic and supportive. There is no known specific antidote, and colchicine is not effectively removed by dialysis.

2023年11月29日 · Strategies to minimize the risk of colchicine poisoning can focus on three broad causes: unauthorized access, intentional overdose and inappropriate dosing. Culturally safe and appropriate education about storage and appropriate use of colchicine is essential to minimize the risk of overdose.

There is no antidote or consistently effective therapy for colchicine toxicity so prevention is the key to avoiding colchicine toxicity and death. This article aims to increase pharmacists' knowledge of colchicine dosing, drug interactions, toxicity and potential therapeutic errors.

2021年7月19日 · Although resuscitation is a priority as with all toxicities, colchicine requires urgent decontamination due to the limited therapies we have once toxic serum levels develop. Toxic Mechanism: Colchicine is used to treat gout, Mediterranean fever and pericarditis.

2022年8月26日 · Meanwhile, there are no management guidelines to treat patients with acute colchicine poisoning until now. Herein, we systematically elaborate on the clinical features and progress in the management of acute colchicine poisoning …

Recent research has focused on understanding the management of colchicine poisoning, exploring treatment options, and developing better diagnostic methods to address this issue effectively.

A recent study found that in clinically relevant porcine models of colchicine toxicity, colchicine-specific antigen-binding fragments (Fabs) can be highly effective if administered in high doses at an early stage.

Colchicine is commonly prescribed for treatment of inflammatory conditions but has a narrow therapeutic window and dangerous toxicity profile. Here we describe a case of survival after massive unintentional colchicine overdose treated with …

1995年3月9日 · The reversal of colchicine poisoning in laboratory animals with the use of colchicine-specific antibodies led us to use this novel approach in a patient with a life-threatening colchicine...