2023年7月17日 · Aplastic anemia refers to the syndrome of chronic primary hematopoietic failure from injury leading to diminished or absent hematopoietic precursors in the bone marrow and attendant pancytopenia. Objectives: Identify the etiology and epidemiology of aplastic anemia medical conditions and emergencies.

Idiopathic acquired aplastic anemia (aAA) is a rare, life threatening bone marrow failure syndrome characterized by cytopenias and a hypocellular bone marrow. Aplastic anemia (AA) is classified as either inherited or acquired.

2022年6月8日 · Aplastic anemia (AA) is a life-threatening form of bone marrow failure which, if untreated, is associated with very high mortality. AA refers to pancytopenia in association with bone marrow hypoplasia/aplasia, most often due to …

2006年10月15日 · Aplastic anemia, an unusual hematologic disease, is the paradigm of the human bone marrow failure syndromes. Almost universally fatal just a few decades ago, aplastic anemia can now be cured or ameliorated by stem-cell …

2022年1月1日 · In this review, we summarize current knowledge on acquired aplastic anemia pathophysiology. Historically, the term “aplastic anemia” identifies a clinical entity where patients present with anemia and an empty marrow by bone marrow (BM) biopsy [1].

2009年9月25日 · Recent advances in understanding the pathogenesis of AA have identified defective telomere maintenance as an important explanation for the onset of marrow failure, relapse and clonal evolution after IST, in some patients with AA.

Aplastic anemia involves panhypoplasia of the bone marrow with anemia, leukopenia, and thrombocytopenia. Many cases are idiopathic, but chemicals, drugs, or radiation may be causes. Bone marrow examination shows a variable degree of hypocellularity.

Historically viewed in isolation as an odd, rare, and invariably fatal blood disease, aplastic anemia is now of substantial interest for its immune pathophysiology, its relationship to constitutional BM failure syndromes and leukemia, and the success of both stem cell transplantation and immunosuppressive therapies in dramatically improving surv...

2022年1月1日 · In this review, we summarize current knowledge on acquired aplastic anemia pathophysiology. Historically, the term “aplastic anemia” identifies a clinical entity where patients present with anemia and an empty marrow by bone marrow (BM) biopsy [1].

The authors review the literature and propose that the major driver of acquired aplastic anemia is a combination of hematopoietic stem and progenitor cells intrinsic defects and an inappropriately activated immune response in the setting of a viral infection. Alterations in bone marrow microenvironment may also contribute to the disease process.