p14ARF (also called ARF tumor suppressor, ARF, p14ARF) is an a lternate r eading f rame protein product of the CDKN2A locus (i.e. INK4a / ARF locus). [1] p14ARF is induced in …

P14ARF is a tumor suppressor encoded by the CDKN2a locus that is frequently inactivated in human tumors. P14ARF protein quenches oncogene stimuli by inhibiting cell cycle progression …

Both proteins are tumor suppressors involved in cell cycle regulation. P16INK4A negatively regulates cell growth by arresting cells at G1; p14ARF enhances apoptosis and blocks …

2000年6月19日 · The INK4a/ARF locus encodes two distinct tumour suppressors, p16 INK4a and p14ARF, that regulate cell cycle progression via the pRB and p53 pathways, respectively. The …

1998年9月10日 · Here we show that E2F-1 directly activates expression of the human tumour-suppressor protein p14ARF (the mouse homologue is called p19ARF), which binds to the …

经典抑癌蛋白ARF由Ink4a/ARF（CDKN2A）基因编码，在人类细胞中表达为p14/ARF，在小鼠细胞中表达为p19/ARF。 大量前期研究表明ARF蛋白可通过阻断泛素连接酶MDM2和ARF …

p14ARF基因（p14ARF gene）是2017年全国科学技术名词审定委员会公布的老年医学名词，出自《老年医学名词》第一版。 肿瘤抑制基因，编码的蛋白能稳定和提高细胞p53水平，具有显著 …

Here, we investigate the role of the tumor suppressor protein p14ARF in maintaining optimal AR activity and the function of the AR itself in regulating p14ARF levels.

2024年8月12日 · The p14ARF tumor suppressor is known to play a fundamental role in cancer progression by regulating senescence, apoptosis, and proliferation. The primary function of …

2017年4月24日 · Here, we present data showing that during cell adhesion and spreading, p14ARF is delocalized from nucleoli to sites of actin polymerization concentrating at focal …