The miR-16 microRNA precursor family is a group of related small non-coding RNA genes that regulates gene expression. miR-16, miR-15, mir-195 and miR-497 are related microRNA precursor sequences from the mir-15 gene family ().This microRNA family appears to be vertebrate specific and its members have been predicted or experimentally validated in a wide range of vertebrate species (MIPF0000006).

2024年12月25日 · MIR16-1 (MicroRNA 16-1) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR16-1 include Pituitary Adenoma and Mantle Cell Lymphoma.Among its related pathways are ncRNAs involved in Wnt signaling in hepatocellular carcinoma and Cell differentiation - expanded index.

The miR-16 is another miRNA related to HBx protein. It belongs to a class of miRNAs, including miR-15a, miR-15b and miR-16, whose genes are located on chromosome 13q and 3 and co-transcribed from DLEU2 and SMC4, respectively, a gene family that regulates the cell cycle by activating the G1/S phase. They target CCND1, CCND3, CCNE1 and CDK6.

2009年6月5日 · MicroRNAs (miRNAs) encoded by the miR-15/16 cluster are known to act as tumor suppressors. Expression of these miRNAs inhibits cell proliferation, promotes apoptosis of cancer cells, and ...

2025年2月8日 · hsa-mir-16-1. GeneRIFs: Gene References Into Functions. Serum microRNAs as new biomarkers for detecting subclinical hemolysis in the nonacute phase of G6PD deficiency. miR-16-5p aggravates sepsis-associated acute kidney injury by inducing apoptosis. The mechanism and therapeutic potential of lncRNA MIR497HG/miR-16-5p axis in breast cancer.

2013年8月14日 · The identification of candidate miR-16 targets by microarray analysis and bioinformatics algorithms. Animal miRNAs were originally believed to block translational processes without affecting transcript levels [1–3].However, recent evidence has changed this view, showing that target mRNA degradation is a widespread effect of miRNA-based regulation that alone accounts for most of the ...

背景技术癌症以其高发病率和高死亡率是全世界主要的公共卫生问题。在先前的几项研究中，MicroRNA-16（miRNA-16，miR-16）家族成员被认为是癌症诊断中的潜在生物标志物，但结果不一致。目的进行本荟萃分析，以系统评估miR-16家族对癌症的诊断功效。方法采用多种搜索策略和随机效应模型。

此外，miR-16-5p的抑癌作用已在不同类型癌症的动物模型中得到验证。这些模型中的研究表明，这种 miRNA 的过度表达或调节吸收这种 miRNA 的 lncRNA 的表达可以阻断致癌过程。在当前的综述中，我们总结了 miR-16-5p 在不同癌症的发生和发展中的作用。

摘要： miRNA(microRNA)是新发现的一类在动植物细胞中广泛表达的小分子非编码RNA(nocoding RNA, ncRNA)分子.通过调控基因的表达,miRNA在生物的生命过程中起着非常重要的作用,即广泛参与机体生长,发育,疾病发生等各种生命过程.近年来从多种生物体中已经鉴定出了数千种miRNA,但只有少数miRNA的靶基因及功能被 ...

MiR-16 is a tumour suppressor that is down-regulated in certain human cancers. However, little is known on its activity in other cell types. In this study, we examined the biological significance and underlying mechanisms of miR-16 on macrophage polarization and subsequent T …