2024年12月25日 · ZBTB16 (Zinc Finger And BTB Domain Containing 16) is a Protein Coding gene. Diseases associated with ZBTB16 include Skeletal Defects, Genital Hypoplasia, And Impaired Intellectual Development and Acute Promyelocytic Leukemia .

2023年12月20日 · We discover that the zinc-finger and BTB domain-containing protein 16 (ZBTB16), also known as promyelocytic leukemia zinc-finger (PLZF), interacts with ASC in the nucleus to control the...

ZBTB16 drives the innate-like effector differentiation of CD1d-restriced iNKT cells. It is specifically and highly expressed in stage 1 (NK1.1-CD44-), and gradually declines thereafter in stage 2 (NK1.1-CD44 +) and stage 3 (NK1.1 + CD44 +) iNKT cells.

2024年4月23日 · These studies suggest that ZBTB16 impedes the progression of lung adenocarcinoma by interfering with WDHD1 transcription, making it a potential novel therapeutic target in the management of lung...

ZBTB16 is a sensitive and specific marker for yolk sac tumour (YST) and is diagnostically superior to AFP and glypican-3 in metastatic and extragonadal settings. Selected gene variants of the transcription factor ZBTB16 influence obesity-related parameters and serum lipid levels.

2017年9月26日 · We summarize the current evidence on relations between an emergent new candidate, zinc finger and BTB domain containing 16 (ZBTB16) transcription factor and the major components constituting the metabolic syndrome.

2021年4月24日 · In this study, we aimed to uncover the roles of ZBTB16 in brain functions and behaviors, as well as how ZBTB16 might be biologically relevant to disorders such as ASD and SCZ by focusing on ...

2025年1月4日 · ZBTB16 is a sensitive and specific marker in detection of metastatic and extragonadal yolk sac tumour. Effects of promyelocytic leukemia zinc finger protein on the proliferation of cultured human corneal endothelial cells. Joko T, Nanba D, Shiba F, Miyata K, Shiraishi A, Ohashi Y, Higashiyama SJoko T, et al. Mol Vis, 2007 Apr 27. PMID 17515885.

Zbtb16 mRNA and protein expression increased during differentiation of mouse brown adipocytes. Overexpression of Zbtb16 in brown adipocytes induced components of the thermogenic program, including genes involved in fatty acid oxidation, glycolysis, and mitochondrial function.

2023年5月19日 · ZBTB16 is the most highly confident direct GR genetarget in both human islets and EndoC-βH1 cells and its substantial glucocorticoid induction may be able to alleviate the cellular stress by improving mitochondrial function as a part of a compensatory mechanism against the β-cell dysfunction triggered by other glucocorticoid targets ...