ZAP70 - Wikipedia
ZAP-70 (Zeta-chain-associated protein kinase 70) is a protein normally expressed near the surface membrane of lymphocytes (T cells, natural killer cells, and a subset of B cells). [5] . It …
癌症免疫治疗相关的TCR信号通路研究新进展 - 知乎
蛋白质组学研究发现lck的负反馈调节主要受zap70影响。抑制zap70催化活性导致lck（y394）磷酸化增加，y192磷酸化降低。y192磷酸化导致lck对cd3ζ链的itam磷酸化减少，改变sh2结构域对 …
T 细胞受体相关蛋白激酶 70 的 zeta 链（ZAP70）基因 | MCE
该基因编码一种属于蛋白酪氨酸激酶家族的酶，它在 T 细胞发育和淋巴细胞活化中发挥作用。 这种酶在 T 细胞抗原受体 (TCR) 刺激后在酪氨酸残基上磷酸化，在 TCR 介导的信号转导的初始步 …
ZAP70 Gene - GeneCards | ZAP70 Protein | ZAP70 Antibody
2024年12月25日 · ZAP70 (Zeta Chain Of T Cell Receptor Associated Protein Kinase 70) is a Protein Coding gene. Diseases associated with ZAP70 include Immunodeficiency 48 and …
ZAP-70: An Essential Kinase in T-cell Signaling - PMC
ZAP-70 is a cytoplasmic protein tyrosine kinase that plays a critical role in the events involved in initiating T-cell responses by the antigen receptor. Here we review the structure of ZAP-70, its …
应用分享 7—免疫治疗中 TCR 信号的单个分子开关——小分子信号 …
2019年11月15日 · Zeta-chain-associated protein kinase 70（ZAP70）是在 T 细胞信号转导过程中具有关键作用的胞质酪氨酸蛋白激酶，当 T 细胞接触到激活信号时，CD3ζ ITAM 发生磷酸化 …
ZAP-70: an essential kinase in T-cell signaling - PubMed
ZAP-70 is a cytoplasmic protein tyrosine kinase that plays a critical role in the events involved in initiating T-cell responses by the antigen receptor. Here we review the structure of ZAP-70, its …
ZAP70 holds the key to kinetic proofreading for TCR ligand ...
2022年8月31日 · In an elegant study using in-depth time-resolved analyses of the total TCR-stimulated phosphoproteome and protein–protein interactions in CD8 + T cells, the authors …
ZAP70 -Related Combined Immunodeficiency - National Center …
2009年10月20日 · ZAP70-related combined immunodeficiency (ZAP70-related CID) is a cell-mediated immunodeficiency caused by abnormal T-cell receptor (TCR) signaling. Affected …
ZAP70: a master regulator of adaptive immunity - PubMed
In this review, we will discuss the role of ZAP70 in T cell activation and focus on what we learnt from pathological conditions associated with defective expression or activity of the ZAP70 kinase.