2022年7月30日 · Our studies suggest that Ym155 binds mitochondrial DNA leading to a decrease in oxidative phosphorylation, decrease in TCA cycle intermediates, and an increase in mitochondrial permeability.

2007年9月1日 · Here, we characterized YM155, a novel small-molecule survivin suppressant, using a survivin gene promoter activity assay. YM155 suppressed expression of survivin and induced apoptosis in PC-3 and PPC-1 human HRPC cell lines at 10 nmol/L.

Sepantronium bromide (YM155; 3 and 10 mg/kg) inhibits the tumor growth in PC-3 xenografts, without obvious body weight loss and blood cell count decrease. Sepantronium bromide is highly distributed to tumor tissue in vivo.

2024年8月20日 · I purchased a YFL-575 loader from a 155D and I'm having trouble finding and sort of schematics or even pictures to help me figure out how/where to connect the hydraulic lines. Assuming you did not get a loader with a separate pump (driven off the front PTO) then Yanmar intended for the B440 selector valve to be installed.

Patients with advanced solid malignancies or lymphoma were treated with escalating doses of YM155 administered by 168-hour continuous intravenous infusion (CIVI). Plasma and urine samples were assayed to determine pharmacokinetic parameters and excretion.

The Yanmar YM155 is a 2WD or 4WD (YM155D) sub-compact utility tractor manufactured by Yanmar from 1976 to 1979. The Yanmar YM155 is equipped with a 0.7 L (40.4 cu·in) two-cylinder diesel engine and a gear type transmission with 6 forward and 2 reverse gears.

2023年4月5日 · YM155 is a highly potent broad-spectrum anti-cancer drug that was derived from a phenotypic screen for functional inhibitors of survivin expression, but for which the relevant biomolecular target remains unknown.

The YM155 is a 15 horsepower, 2 cylinder diesel tractor manufactured in Japan for sale in the US market. It was manufactured between 1976 up to 1979. The tractor was available in a 2wd YM155 version as well as the 4wd YM155D version.

2023年2月1日 · YM155 (sepantronium bromide) is a small-molecule agent with antitumor activity in vitro and in vivo (Rauch et al., 2014). YM155 may suppress survivin expression at both the mRNA and protein levels by repressing its promoter activity (Nakahara et …