
抗癌靶点XPO1「图鉴」 - 知乎 - 知乎专栏
核输出蛋白1(exportin 1,XPO1)又称染色体区域稳定蛋白1,通过调节从细胞核到细胞质的一系列“货物”(包括蛋白质和几种RNA)的输出,在维持细胞内稳态中起着至关重要的作用。
XPO1 - Wikipedia
Exportin 1 (XPO1), also known as chromosomal region maintenance 1 (CRM1), is a eukaryotic protein that mediates the nuclear export of various proteins and RNAs.
XPO1 Gene - GeneCards | XPO1 Protein | XPO1 Antibody
2024年12月25日 · XPO1 (Exportin 1) is a Protein Coding gene. Diseases associated with XPO1 include Leukemia, Chronic Lymphocytic and Primary Mediastinal Large B-Cell Lymphoma. …
The nuclear export protein XPO1 — from biology to targeted …
2020年11月10日 · The nuclear export protein exportin 1 (XPO1) is crucial for the maintenance of cellular homeostasis as it mediates the transport of >200 proteins, many of which...
The nuclear export protein XPO1 provides a peptide ligand for …
2024年8月23日 · XPO1 (Exportin-1/CRM1) is a nuclear export protein that is frequently overexpressed in cancer and functions as a driver of oncogenesis. Currently small molecules …
Targeting XPO1 for fighting relapsed/refractory diseases: The …
2025年1月1日 · The discovery reveals a new role for XPO1 in immune regulation and provides a theoretical basis for developing innovative therapeutic strategies for autoimmune diseases. …
选择性XPO1抑制剂在急性髓系白血病治疗中的研究进展
核输出蛋白1(exportin 1, XPO1)是细胞中最关键也是研究最广泛的核质转运蛋白,既往研究证实XPO1在多种血液肿瘤和实体瘤中均有过表达,并且与疾病进展、药物抵抗及预后相关 ,提示 …
抗癌靶点XPO1「图鉴」|介导|单抗|米松|免疫_网易订阅
2020年12月22日 · 核输出蛋白1(exportin 1,XPO1)又称染色体区域稳定蛋白1,通过调节从细胞核到细胞质的一系列“货物”(包括蛋白质和几种RNA)的输出,在维持细胞内稳态中起着至关 …
核输出蛋白 XPO1——从生物学到靶向治疗,Nature Reviews Clinical …
输出蛋白 1 (xpo1) 也称为染色体区域维持蛋白 1,通过调节一系列货物(包括蛋白质和几类 rna)从细胞核到细胞质的输出,在维持细胞稳态中发挥着至关重要的作用。
Targeting XPO1 enhances innate immune response and inhibits
2021年1月4日 · These results illustrate a novel mechanism by which XPO1 mediates innate immune response and KSHV replication, and identify XPO1 as a potential therapeutic target …