
The vesicular GABA transporter, VGAT, localizes to synaptic ... - PubMed
1998年12月1日 · This vesicular GABA transporter (VGAT), the first vesicular amino acid transporter to be molecularly identified, differs in structure from previously cloned vesicular neurotransmitter transporters and defines a novel gene family.
The Vesicular GABA Transporter, VGAT, Localizes to Synaptic …
Here we use antibodies specific for N- and C-terminal epitopes of VGAT to localize the protein in the rat CNS. VGAT is highly concentrated in the nerve endings of GABAergic neurons in the brain and spinal cord but also in glycinergic nerve endings.
Vesicular GABA transporter (VGAT) transports β-alanine
Vesicular GABA transporter (VGAT) is expressed in GABAergic and glycinergic neurons, and is responsible for vesicular storage and subsequent exocytosis of these inhibitory amino acids. In this study, we show that VGAT recognizes β-alanine as a substrate.
Synaptic Systems - VGAT
The vesicular GABA transporter VGAT is responsible for uptake and storage of GABA and glycine by synaptic vesicles in the central nervous system.
Vesicular glutamate (VGlut), GABA (VGAT), and acetylcholine …
2006年6月1日 · In the LH, the BDA-labeled varicosities were immunopositive (+) for VAChT ( approximately 10%), VGluT2 ( approximately 25%), or VGAT ( approximately 50%), revealing an important influence of newly identified glutamatergic together with GABAergic BF inputs.
Co-existence of Functionally Different Vesicular Neurotransmitter ...
The vesicular transmitter transporters VGLUT, VGAT, VMAT2 and VAChT, define phenotype and physiological properties of neuronal subtypes. VGLUTs concentrate the excitatory amino acid glutamate, VGAT the inhibitory amino acid GABA, VMAT2 monoamines, and VAChT acetylcholine (ACh) into synaptic vesicle (SV).
Vesicular GABA transporter (VGAT) transports β-alanine
2013年8月6日 · Vesicular GABA transporter (VGAT) is expressed in GABAergic and glycinergic neurons, and is responsible for vesicular storage and subsequent exocytosis of these inhibitory amino acids. In this study, we show that VGAT recognizes β-alanine as a substrate.
Unique Luminal Localization of VGAT-C Terminus Allows for …
Using epitope-specific antibodies and mass spectrometry we show that the vesicular GABA transporter (VGAT) possesses an uneven number of transmembrane domains, with the N terminus facing the cytoplasm and the C terminus residing in the synaptic vesicle lumen.
Vesicular Inhibitory Amino Acid Transporter - an overview ...
In the brain superfamily SLC32, SLC36, SLC38 the vesicular inhibitory amino acid transporter (VIAAT) or vesicular GABA transporter (VGAT) is present on synaptic vesicles of GABAergic and glycinergic neurons [103]. VGAT is organized into ten membrane spanning domains, a cytosolic N-terminus and a luminal C-terminal tail [104].
The physiological roles of vesicular GABA transporter during …
2010年12月30日 · The vesicular GABA transporter (VGAT) loads GABA and glycine from the neuronal cytoplasm into synaptic vesicles. To address functional importance of VGAT during embryonic development, we generated global VGAT knockout mice and analyzed them.
- 某些结果已被删除