VEGF-A binds to VEGFR-1 (Flt-1) and VEGFR-2 (KDR/Flk-1). VEGFR-2 appears to mediate almost all of the known cellular responses to VEGF. [1] . The function of VEGFR-1 is less well defined, although it is thought to modulate VEGFR-2 signaling.

Human VEGFR-2, a kinase insert domain containing receptor (KDR) gene, is located at chromosome locus 4q11-12 and encodes 1356 amino acids of the full-length receptor (Park et al., 2018). Mature VEGFR-2 is a transmembrane glycoprotein with a molecular weight of 230 kD (Figure 1; Takahashi and Shibuya, 1997).

2016年7月27日 · This paper describes how VEGF–VEGFR2 on an endothelial cell can bind to NRP1 on an adjacent cell (that is, trans-binding), regulating VEGFR2 endocytosis, tumour initiation and tumour...

2019年6月1日 · Angiogenesis inhibition by blocking the VEGFR-2 is an emerging strategy to develop selective and specific anticancer agents. The review articles published before were based on the structure and biology of VEGFR-2 rather than medicinal chemistry.

VEGFR2 is a promising marker for malignant vascular tumors and malignant epithelioid mesothelioma. Expression in biphasic synovial sarcoma epithelium, chordoma, and some carcinomas has to be considered in differential diagnosis.

2020年11月16日 · Based on the molecular structure and signaling pathways of VEGFR-2, the strategy of the VEGFR-2-targeted therapy should be considered to employ in the treatment of the VEGF/VEGFR-2-associated diseases by blocking the VEGF/VEGFR-2 signaling pathway, inhibiting VEGF and VEGFR-2 gene expression, blocking the binding of VEGF and VEGFR-2, …

2017年8月7日 · Vascular endothelial growth factor receptor-2 (VEGFR2) is the main pro-angiogenic receptor expressed by endothelial cells (ECs).

VEGFR2 is implicated in all aspects of normal and pathological vascular-endothelial-cell biology, whereas VEGFR3 is important for lymphatic-endothelial-cell development and function.

Vascular endothelial growth factor (VEGF) is the main driver of angiogenesis and vascular permeability via VEGF receptor 2 (VEGFR2), whereas lymphangiogenesis signals are transduced by VEGFC/D via VEGFR3.

VEGFR-1 is required for the recruitment of haematopoietic stem cells and the migration of monocytes and macrophages, VEGFR-2 regulates vascular endothelial function and VEGFR-3 regulates lymphatic endothelial cell function.