Vitamin K epOxide Reductase Complex subunit 1 (VKORC) is an enzyme that in humans is encoded by the VKORC1 gene. [5] This enzymatic protein complex is responsible for reducing vitamin K 2,3-epoxide to its active form, which is important for effective clotting (coagulation). [6]

The VKORC1 gene encodes the VKORC1 (vitamin K epoxide reductase) protein, which is a key enzyme in the vitamin K cycle [1,2]. VKORC1 is a 163 amino acid integral membrane protein associated with the endoplasmic reticulum and VKORC1 mRNA is broadly expressed in many different tissues .

2012年3月8日 · The VKORC1 gene encodes the vitamin K epoxide reductase enzyme, which catalyzes the rate-limiting step in vitamin K recycling (converting vitamin K epoxide to vitamin K). This enzyme is also the drug target for warfarin.

2024年12月25日 · VKORC1 (Vitamin K Epoxide Reductase Complex Subunit 1) is a Protein Coding gene. Diseases associated with VKORC1 include Vitamin K-Dependent Clotting Factors, Combined Deficiency Of, 2 and Coumarin Resistance .

The VKORC1 gene provides instructions for making a vitamin K epoxide reductase enzyme. The VKORC1 enzyme is made primarily in the liver. It spans the membrane of a cellular structure called the endoplasmic reticulum, which is involved with protein processing and transport.

Polymorphisms in the vitamin K-epoxide reductase complex subunit 1 gene, Vkorc1, could affect blood coagulation and other vitamin K-dependent proteins, such as osteocalcin (bone Gla protein, BGP). Here we sequenced the Vkorc1 gene in 40 mouse priority strains.

2024年9月18日 · Go to Variation Viewer for VKORC1 variants Summary This gene encodes the catalytic subunit of the vitamin K epoxide reductase complex, which is responsible for the reduction of inactive vitamin K 2,3-epoxide to active vitamin K in …

2025年2月8日 · Vitamin K is a required co-factor for carboxylation of glutamic acid residues by vitamin K-dependent gamma-carboxylase in blood-clotting enzymes.

2021年12月17日 · The VKORC1 gene encodes vitamin K epoxide reductase complex subunit-1, a small transmembrane protein of the endoplasmic reticulum, which plays a major role in the vitamin K pathway and is the target protein of warfarin (summary by Ross et al., 2010).

Genetic studies have shown that the VKORC1 gene extends over 5126 base pairs on human chromosome 16 and comprises three exons. Mutations in the VKORC1 gene causes generalized defective vitamin K-dependent clotting factors (VKCFD2) and warfarin resistance (WR).