UDP-alpha - D-glucuronic acid is a UDP-sugar having alpha-D-glucuronic acid as the sugar component. It has a role as a human metabolite, an Escherichia coli metabolite and a mouse metabolite. It is functionally related to an alpha-D-glucuronic acid. It is a conjugate acid of an UDP-alpha-D-glucuronate (3-).

Uridine 5′-diphosphate-glucuronic acid (UDP-GlcA) is a carboxylic acid-formed sugar nucleotide. It participates in the biosynthesis of numerous cell components. [3] .

UDP–glucuronic acid is utilized in biosynthetic reactions that involve condensation of glucuronic acid with a variety of molecules to form an ether (glycoside), an ester, or an amide, depending on the nature of the acceptor molecule. You might find these chapters and articles relevant to this topic. In Dictionary of Toxicology (Third Edition), 2015

The uridine diphosphate (UDP)-glucuronosyltransferases (UGT) are a family of enzymes that catalyse the covalent addition of glucuronic acid to a wide range of lipophilic chemicals.

UDP-glycosyltransferases (UGTs) are a superfamily of enzymes found in animals, plants, fungi, and germs that catalyze the covalent addition of sugars from nucleotide UDP sugar donors to functional groups on a variety of lipophilic compounds. There are 22 UGTs in humans.

Uridine 5′-diphospho (UDP)-glucuronosyltransferases (UGTs) are a superfamily of phase II enzymes which have roles in the conjugation of xenobiotics or endogenous compounds, including drugs and bilirubin, with glucuronic acid to make them easier to excrete.

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2025年1月15日 · Human UDP-glucuronosyltransferases (UGTs) are pivotal phase II metabolic enzymes facilitating the transfer of glucuronic acid from UDP-glucuronic acid (UDPGA) to various substrates. UGTs are classic type I transmembrane glycoproteins, mainly localized in the endoplasmic reticulum (ER) membrane.

Chen et al. found that the metabolite uridine diphosphate glucose (UDPG), which is produced during glycogenesis, is transported to the Golgi apparatus, where it blocks a protease called S1P and thereby inhibits lipogenesis.

Glucuronidation mediated by UDP-glucuronosyltransferases (UGTs) is a significant metabolic pathway that facilitates efficient elimination of numerous endo- and xenobiotics including phenolics.