USP9X is a protein-coding gene that has been implicated either directly through mutations or indirectly in a number of neurodevelopmental and neurodegenerative disorders. Three …

2024年12月25日 · USP9X (Ubiquitin Specific Peptidase 9 X-Linked) is a Protein Coding gene. Diseases associated with USP9X include Intellectual Developmental Disorder, X-Linked 99, …

The X-linked deubiquitinase USP9X has been implicated in multiple pathological disorders including malignancies and X-linked intellectual disability. However, its biological function and …

USP9X promotes the deubiquitination and stabilization of diverse substrates, thereby exerting a versatile range of effects on pathological and physiological processes. USP9X serves vital …

2017年3月31日 · We demonstrate that USP9X is an integral component of centrosome and is required for centrosome biogenesis. Loss-of-function of USP9X impairs centrosome …

Previously, as part of a large systematic resequencing of the X chromosome in 208 unrelated families with nonsyndromic X-linked intellectual disability, we identified three unique variants …

USP9X is a key deubiquitinase for ALDH1A3 protein stabilization and a potential target for glioblastoma stem cell-directed therapy; show that USP9X-mediated BCL9 deubiquitination …

2021年3月25日 · Usp9x is a marker of “stemness” and is mutated in various neurological disorders and cancers. Our results unveil a Usp9x-PRC2 regulatory axis that is critical at peri …

Lei et al. demonstrate that USP9X is a key deubiquitinase controlling Wnt signaling by stabilizing β-catenin in the central nervous system (CNS) vasculature. Loss of USP9X in CNS endothelial …

2024年5月1日 · In this review, we provide a comprehensive delineation of USP9X participation in numerous critical cellular processes, complicated signaling pathways within the tumor …