UGT2B7 (UDP-Glucuronosyltransferase-2B7) is a phase II metabolism isoenzyme found to be active in the liver, kidneys, epithelial cells of the lower gastrointestinal tract and also has been reported in the brain.

2024年12月25日 · UGT2B7 (UDP Glucuronosyltransferase Family 2 Member B7) is a Protein Coding gene. Diseases associated with UGT2B7 include Hepatocellular Adenoma and Neonatal Abstinence Syndrome. Among its related pathways are Metapathway biotransformation Phase I and II and Drug ADME.

UDP-glucuronosyltransferases (UGTs) are phase II drug-metabolizing enzymes that metabolize endogenous fatty acids such as arachidonic acid metabolites, as well as many prescription drugs, such as opioids, antiepileptics, and antiviral drugs.

UGT2B7 polymorphisms may play a crucial role in the occurrence and development of breast cancer in the Han Chinese population; UGT2B7 could localize to the ER without any retention signal. UGT2B7 rs7439366 increased the colorectal cancer risk in dominant model (OR=0.76, 95% CI=0.61-0.95, P=0.02).

UDP-glucuronosyltransferase 2B7 (UGT2B7) is one of the most significant isoforms of UGTs in human liver. This research measured UGT2B7 protein content and activities, including maximum velocity (V max ) and intrinsic clearance (CL int ), in human liver at isoform, microsomal, liver …

UGT2B7 is a type of enzyme that belongs to the UGT superfamily, characterized by a specific signature sequence in its C-terminal domain. It plays a crucial role in binding UDP-sugars and is involved in the metabolism of various compounds in the body.

The 1.8-Å resolution apo crystal structure of the UDP-glucuronic acid binding domain of human UGT2B7 (2B7CT) is the only structure of a mammalian UGT target determined to date. In this review, we summarize what has been learned about human UGT function from the analysis of this and other related glycosyltransferase (GT) crystal structures.

2015年2月1日 · UGT2B7: UGT2B7 is arguably the most important isoform because it contributes to the glucuronidation of 35% of clinically used drugs [1]. This enzyme catalyzes the glucuronidation of opioid drugs including morphine, codeine, buprenorphine, and naloxone [158] , anti-viral drugs including zidovudine [111] and efavirenz [159] , and other carboxylic ...

2020年2月12日 · One notable exception is the glucuronidation of morphine by the enzyme UGT2B7, which produces morphine-6-glucuronide with enhanced analgesic activity relative to morphine.

Title: Metabolism and Toxicity of Emodin: Genome-Wide Association Studies Reveal Hepatocyte Nuclear Factor 4α Regulates UGT2B7 and Emodin Glucuronidation. The N(6)-methyladenosine modification posttranscriptionally regulates hepatic UGT2B7 expression.