U-937 is a suspension cell line isolated from malignant cells from the pleural effusion of a patient with histiocytic lymphoma. These cells are pro-monocytic but can differentiate into macrophage or dendric cells depending on culture conditions; this makes it a …

In this study, we used a standardized differentiation protocol using PMA and compared the response of macrophages derived from THP-1 and U937 cells to M1-and M2-polarizing conditions.

established from the pleural effusion of a 37-year-old man with generalized diffuse histiocytic lymphoma in 1974; cells were described in the literature to express markers and properties of monocytes; patented cell line. Exome and RNA sequence data are available (see Ref 18187 and Exome sequence and RNA-Seq)

U937 is a pro-monocytic, human myeloid leukaemia cell line and was isolated from the histiocytic lymphoma of a 37 year old male (Sundstrom and Nilsson 1976). This cell line exhibits many characteristics of monocytes and is easy to use.

This chapter describes how to grow THP-1, resp. U937 cells, how to differentiate these into more specialised phenotypes such as various macrophage types or dendritic cells, how to read-out their responses to stimuli and it gives examples of how such cell lines have been used into studying the effects of food compounds.

U937 is a pro-monocytic, human myeloid leukaemia cell line and was isolated from the histiocytic lymphoma of a 37 year old male (Sundstrom and Nilsson 1976). This cell line exhibits many characteristics of monocytes and is easy to use.

The U937 cell line facilitates the examination of macrophage function, including phagocytic activity and the neurobiology of cytokines, which are crucial for understanding inflammatory responses and immune regulation.

U937 cells were evaluated for their ability to phagocytose Mycobacterium tuberculosis and for their ability to present mycobacterial antigens to human HLA class I-matched cytotoxic T lymphocytes (CTLs).

In this study, we screened seven human cell lines and found that the human monocytic cell U937 supports the replication of different subtypes of influenza viruses as well as the production of the important pro-inflammatory cytokines and was selected to develop the cell-based model.

The U937 cell line is a well-characterized human lymphoma cell line of Caucasians, and is considered as a potential in vitro model of schizophrenia (Obajimi et al., 2005).