Non-receptor tyrosine-protein kinase TYK2 is an enzyme that in humans is encoded by the TYK2 gene. [5] [6] TYK2 was the first member of the JAK family that was described (the other members are JAK1, JAK2, and JAK3). [7] It has been implicated in IFN-α, IL-6, IL-10 and IL-12 signaling.

Tyrosine kinase 2 (TYK2) is an intracellular enzyme that mediates immune signaling and inflammatory signaling pathways. 1-7 TYK2 is important in both innate and adaptive immune cells and is an essential component of

Studies on Tyk2-deficient mice or human patients with mutated Tyk2 alleles have revealed that Tyk2 is a key player in the pathogenesis of autoimmune and/or inflammatory diseases. Imatinib, a Bcr-Abl kinase inhibitor, exerts potent therapeutic effects in …

2024年3月11日 · Tyrosine kinase 2 (TYK2), a Janus kinase family member, is involved in immune signalling and is implicated in autoimmune diseases such as systemic lupus erythematosus; inhibitors of TYK2...

Tyk2 participates in the signaling of multiple regulatory and effector cytokines involved in psoriasis [10,44], and Tyk2 dysfunctional mutations are protective for psoriasis [10,22]. Thus, Tyk2 is an attractive druggable target, and multiple Tyk2 inhibitors are being investigated [10,13,22].

2024年12月25日 · TYK2 (Tyrosine Kinase 2) is a Protein Coding gene. Diseases associated with TYK2 include Immunodeficiency 35 and Primary Cutaneous Anaplastic Large Cell Lymphoma. Among its related pathways are Overview of interferons-mediated signaling pathway and Interleukin-12 family signaling.

2024年11月11日 · Partial inhibition of TYK2 mitigates tau pathologies in cells and mice, highlighting TYK2 as a potential therapeutic target for Alzheimer’s disease and other tauopathies.

TYK2 is an intracellular kinase critical for the relay of immune signals initiated by proinflammatory cytokines such as IL-23, IL-12, and the Type I IFNs. Additional TYK2 pathway cytokines relevant to psoriatic arthritis (PsA) include IL-22 and IFN-λ. 23-25. IL-23 induces the production of both IL-17 and IL-22 26; IL-12 drives the production ...

2024年2月13日 · TYK2 is a candidate susceptibility gene for type 1 diabetes (T1D) and a beneficial effect has been reported for TYK2 inhibitors for other autoimmune diseases.

Learn more about the tyrosine kinase 2 (TYK2) pathway, its role in managing the inflammatory signals in psoriasis, and see the TYK2 pathway in action.