Trop2 and its overexpression in cancers: regulation and clinical ...
Trop2 is a transmembrane glycoprotein encoded by the Tacstd2 gene. It is an intracellular calcium signal transducer that is differentially expressed in many cancers. It signals cells for self …
Trop-2 protein as a therapeutic target: A focused review on Trop-2 ...
Trop-2 (also called epithelial glycoprotein-1, gastrointestinal antigen 733-1, membrane component surface marker-1, and tumor-associated calcium signal transducer-2), is a product of the …
Targeting Trop-2 in cancer: Recent research progress and clinical ...
2023年7月1日 · Trophoblast surface antigen 2 (Trop-2) is a type I transmembrane glycoprotein involved in Ca2+ signaling in tumor cells. It is highly expressed in various tumor tissues than in …
Targeting Trop-2 in solid tumors: future prospects - PMC
Trop-2 is an ideal candidate for targeted therapeutics due to it being a transmembrane protein with an extracellular domain overexpressed on a wide variety of tumors as well as its …
TACSTD2 - Wikipedia
Tumor-associated calcium signal transducer 2, also known as Trop-2 and as epithelial glycoprotein-1 antigen (EGP-1) [5] is a protein that in humans is encoded by the TACSTD2 …
Targeting Trop-2 in solid tumors: future prospects - PubMed
2019年3月1日 · Trop-2 is an ideal candidate for targeted therapeutics due to it being a transmembrane protein with an extracellular domain overexpressed on a wide variety of …
Trop2 and its overexpression in cancers: regulation and ... - PubMed
Trop2 is a transmembrane glycoprotein encoded by the Tacstd2 gene. It is an intracellular calcium signal transducer that is differentially expressed in many cancers. It signals cells for self …
A new TROP2-targeting antibody-drug conjugate shows potent
2024年4月23日 · Trophoblast cell surface antigen 2 (Trop2) is considered to be an attractive therapeutic target in cancer treatments. We previously generated a new humanized anti-Trop2 …
Overview of Trop-2 in Cancer: From Pre-Clinical Studies to Future ...
2023年3月13日 · In our work, we briefly summarize the various characteristics of cancer cells overexpressing Trop-2, the pre-clinical activities of specific inhibitors, and the role of anti-Trop …
Targeting Trop-2 in solid tumors: future prospects
2019年3月1日 · Trop-2 is an ideal candidate for targeted therapeutics due to it being a transmembrane protein with an extracellular domain overexpressed on a wide variety of …