Tropomyosin receptor kinase B (TrkB), [5] [6] [7] also known as tyrosine receptor kinase B, or BDNF/NT-3 growth factors receptor or neurotrophic tyrosine kinase, receptor, type 2 is a protein that in humans is encoded by the NTRK2 gene. [8] TrkB is a receptor for brain-derived neurotrophic factor (BDNF). [9] [10] The standard pronunciation for this protein is "track bee".

(A) Schematic representation of the genomic structure of the murine TrkB gene. Exons are shown as boxes and introns are shown as lines. White and black stars indicate the start and stop condons, respectively. Color of exons indicate the domains of the TrkB protein isoforms shown in panel (B).Gray boxes indicate the 3′ untranslated region (UTR) of the TrkB transcripts.

BDNF-mediated effects on neuronal structure and function. (A) BDNF and proBDNF are released at postsynaptic sites. BDNF binds TrkB with high affinity to induce its dimerization and phosphorylation at tyrosine residues in the cytoplasmatic domain, which serves as a docking site for several downstream signaling pathways.

2004年3月15日 · Although it is well established that both follicular assembly and the initiation of follicle growth in the mammalian ovary occur independently of pituitary hormone support, the factors controlling these processes remain poorly understood. We now report that neurotrophins (NTs) signaling via TrkB rec …

Brain-derived neurotrophic factor (BDNF) and its receptor tropomyosin-related kinase receptor type B (TrkB) are widely distributed in multiple regions of the human brain. Specifically, BDNF/TrkB is highly expressed and activated in the dopaminergic ...

2024年3月2日 · TrkB (neuronal receptor tyrosine kinase-2, NTRK2) is the receptor for brain-derived neurotrophic factor (BDNF) and is a critical regulator of activity-dependent neuronal plasticity. The past few years have witnessed an increasing understanding of the structure and function of TrkB, including its transmembrane domain (TMD). TrkB interacts with membrane …

In recent years, a role has been proposed for the neurotrophin receptor tyrosine kinase TrkB in synaptic plasticity, learning and memory. Liliana Minichiello discusses the signalling pathways ...

TrkA, trkB, p75 and NGF-null Mice. TrkA +/− (129Sv-C57BL/6) mice (Liebl et al. 2000) were a generous gift of Dr. Lino Tesarollo (National Cancer Institute, Frederick, MD). Ngf +/− (C57BL/6-AB1) mice (Crowley et al. 1994) were kindly provided by Dr. Heike Phillips (University of California at San Francisco, CA) and p75 NTR+/− (BALB/c) mice (Lee et al. 1992) were generously …

Tropomyosin-related kinase (TRK) receptor B (TRKB) mediates the supportive actions of neurotrophin 4/5 and brain-derived neurotrophic factor on early ovarian follicle development. Absence of TRKB receptors reduces granulosa cell (GC) proliferation and delays follicle growth. In the present study, we …

2024年1月1日 · Mature neurotrophic factors primarily function as non-covalently linked homodimers, such as NT-3/NT-3. However, some neurotrophic factors can also form heterodimers with other neurotrophic factors, for instance, known heterodimers like NT-3/BDNF and NT-4/BDNF, which play a role in neuronal protection [8].Neurotrophic factors exert …