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Toshiro SATO, Associate Professor | Cited by 31,319 | of Keio University, Tokyo | Read 158 publications | Contact Toshiro SATO

2022年7月7日 · Here we develop a live genetic lineage-tracing system that allows the longitudinal tracking of individual cells in xenotransplanted human colorectal cancer organoids, and identify LGR5 + cancer...

2021年2月24日 · Here we generate a functional small intestinalized colon (SIC) by replacing the native colonic epithelium with ileum-derived organoids. We first find that xenotransplanted human ileum organoids...

2013年6月7日 · Lgr5, the receptor for the Wnt-agonistic R-spondins, marks stem cells in multiple adult organs of mice and humans. In R-spondin-based three-dimensional cultures, these Lgr5 stem cells can grow into ever-expanding epithelial organoids that …

Here, we identify Klebsiella pneumonia in the microbiota of patients with PSC and demonstrate that K. pneumoniae disrupts the epithelial barrier to initiate bacterial translocation and liver inflammatory responses.

Toshiro SATO, Associate Professor | Cited by 29,320 | of Keio University, Tokyo | Read 157 publications | Contact Toshiro SATO

Toshiro Sato Professor Department of Organoid Medicine, Keio University School of Medicine JAPAN Gastroenterology Education Background 4/1991-3/1997 MD Keio University School of Medicine 4/1997-3/1999 Internship, Keio University Hospital 4/1999-3/2003 Internal Medicine, Graduate school, School of Medicine, Keio University 4/2004 PhD

Conclusions: We developed a technology that can be used to study infected, inflammatory, or neoplastic tissues from the human gastrointestinal tract. These tools might have applications in regenerative biology through ex vivo expansion of the intestinal epithelia.

2020年5月26日 · Using organoid cultures to study ulcerative colitis, Prof. Sato’s research team has shown for the first time that inflamed colonic epithelial cells accumulate a specific gene mutation that is insensitive to interleukin 17 (IL-17), a …