Tumor necrosis factor (TNF), formerly known as TNF-α, is a chemical messenger produced by the immune system that induces inflammation. [5] . TNF is produced primarily by activated macrophages, and induces inflammation by binding to its receptors on other cells. [6] .

Tumor necrosis factor alpha (TNF-α) was initially recognized as a factor that causes the necrosis of tumors, but it has been recently identified to have additional important functions as a pathological component of autoimmune diseases. TNF-α binds to two different receptors, which initiate signal transduction pathways.

2024年12月25日 · This gene encodes a multifunctional proinflammatory cytokine that belongs to the tumor necrosis factor (TNF) superfamily. This cytokine is mainly secreted by macrophages. It can bind to, and thus functions through its receptors TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR.

2010年1月19日 · Understanding the mechanisms underlying inflammation-mediated metastasis will reveal new therapeutic targets for cancer prevention and treatment. Tumour necrosis factor (TNF)- α is a key...

2023年11月14日 · Tumor necrosis factor (TNF) is a protein you have in your body. It's important for your immune system to work the way it should to protect you. It's also involved in healing....

2021年3月8日 · In this review, we briefly introduce the impact of TNF-α signaling on autoimmune diseases and its inhibitors, which are used as therapeutic agents against autoimmune diseases. Keywords: TNF-α; TNF-α inhibitors; autoimmune diseases; inflammatory bowel disease; psoriatic arthritis; rheumatoid arthritis.

2000年8月1日 · Tumour Necrosis Factor alpha (TNF alpha), is an inflammatory cytokine produced by macrophages/monocytes during acute inflammation and is responsible for a diverse range of signalling events within cells, leading to necrosis or apoptosis. The protein is also important for resistance to infection and cancers.

2023年12月19日 · Tumor necrosis factor (TNF) is a type of cytokine. This is a signaling protein made by your white blood cells. Cytokines are released during an immune system response to threats such as tumor cells, viruses, and bacteria. TNF triggers the inflammatory process to fight threats to your body. However, too much TNF can result in excess inflammation.

Tumor Necrosis Factor Alpha (TNF-α) is a cytokine that acts as an arbitrator of the local tissue environment following injury, and is involved in bone tissue regeneration. It can initiate apoptosis and regulate cell survival and proliferation.

2022年11月15日 · Tumour necrosis factor (TNF) is a central cytokine in inflammatory reactions, and biologics that neutralize TNF are among the most successful drugs for the treatment of chronic inflammatory...

Tumor necrosis factor (TNF) is a critical cytokine, which contributes to both physiological and pathological processes. This mini-review will briefly touch the history of TNF discovery, its family members and its biological and pathological functions.

TNFα signals through two transmembrane receptors, TNFR1 and TNFR2, and regulates a number of critical cell functions including cell proliferation, survival, differentiation, and apoptosis. Macrophages are the major producers of TNFα and interestingly are also highly responsive to …

2024年11月25日 · Increased TNFα expression is sufficient to promote both intestinal and hepatobiliary inflammation and fibrotic injury and contributes to hepatic dysregulation of FXR signaling and bile acid homeostasis. Overall, these results suggest that the TNF∆ARE+/- mouse may be a useful model for studying chron …

2021年3月8日 · Tumor necrosis factor alpha (TNF-α) was initially recognized as a factor that causes the necrosis of tumors, but it has been recently identified to have additional important functions as a pathological component of autoimmune diseases. TNF-α binds to two different receptors, which initiate signal transduction pathways.

2019年4月1日 · Tumor necrosis factor is a protein found in the human body. Doctors link it with many inflammatory conditions, including forms of arthritis. In a healthy person, tumor necrosis factor (TNF)...

Tumor necrosis factor-alpha (TNF-α) is a pleiotropic immune cytokine that belongs to the TNF superfamily of receptor ligands.

2021年7月29日 · Tumor necrosis factor alpha (TNF-α) plays important roles in processes such as immunomodulation, fever, inflammatory response, inhibition of tumor formation, and inhibition of viral replication.

vascular calcification induced by TNFa, (4) CKD induces aortic TNFa, ATF4, and CHOP expression, and (5) inhibition of TNFa attenuates CKD-dependent vascular calcification in ApoE / mice with 5/6 nephrectomies by reducing aortic PERK-eIF2a-ATF4-CHOP signaling of the ER stress response. Methods Cell Culture Studies

At >24 weeks of age, TNF ΔARE mice developed structural, histologic, and transcriptional changes of ileal fibrosis. Protein and RNA expression profiles showed changes as early as 6 weeks, coinciding with histologic changes as early as 14 to 15 weeks.

Results: We saw an 80-fold increase in ccl2 and a 30-fold elevation in tnfa after injury in the whole brain of aged mice compared to young groups and aged sham mice (p < 0.05 and p < 0.05, respectively). Additionally, there was a 30-fold increase in ccl2 within isolated HPC of aged injured mice when compared to sham injured animals (p < 0.05).