2024年12月25日 · TLK1 (Tousled Like Kinase 1) is a Protein Coding gene. Diseases associated with TLK1 include Pica Disease and Castration-Resistant Prostate Carcinoma. Among its related pathways are miRNA regulation of DNA damage response and ATM Pathway.

Serine/threonine-protein kinase tousled-like 1 is an enzyme that in humans is encoded by the TLK1 gene. [5][6][7] The Tousled-like kinases, first described in Arabidopsis, are nuclear serine/threonine kinases that are potentially involved in the regulation of chromatin assembly. [supplied by OMIM] [7]

TLK1-mediated MK5-S354 phosphorylation drives prostate cancer cell motility and may signify distinct pathologies. CircTLK1 modulates sepsis-induced cardiomyocyte apoptosis via enhancing PARP1/HMGB1 axis-mediated mitochondrial DNA damage by sponging miR-17-5p.

2017年7月14日 · The Tousled-like kinases, TLK1 and TLK2, regulate ASF1, a histone H3/H4 chaperone, and likely other substrates, and their activity has been implicated in transcription, DNA replication, DNA...

2018年6月28日 · In humans, the similar TLK1 and TLK2 interact with each other and TLK activity enhances ASF1 histone binding and is inhibited by the DNA damage response, although the molecular mechanisms of TLK...

In addition, the TLKs have been clearly linked to human disease; both TLK1 and TLK2 are frequently amplified in human cancers and TLK2 mutations have been identified in patients with neurodevelopmental disorders characterized by intellectual disability (ID), autism spectrum disorder (ASD) and microcephaly.

该基因编码的蛋白质是一种丝氨酸/苏氨酸激酶，可能参与染色质组装的调节。 编码的蛋白质只有在磷酸化时才有活性，这种磷酸化依赖于细胞周期，该蛋白质的最大活性出现在 S 期。 这种蛋白质的催化活性会因 DNA 损伤和 DNA 复制受阻而减弱。 已发现该基因的三个转录变体编码不同的亚型。 [RefSeq 提供，2011 年 11 月] The protein encoded by this gene is a serine/threonine kinase that may be involved in the regulation of chromatin assembly.

2024年4月22日 · Tousled-like kinases 1 and 2 (TLK1 and 2) are cell cycle-regulated serine/threonine kinases that are involved in multiple biological processes. Mutation of TLK1 and 2 confer neurodegenerative diseases. Recent studies …

TLK1 Antibody detects endogenous levels of total TLK1. The antibody may cross-react with TLK2. Human, Mouse, Rat. Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues adjacent to Ser183 of human TLK1. Antibodies are purified by protein A and peptide affinity chromatography.

Predicted to enable ATP binding activity and protein serine/threonine kinase activity. Predicted to be involved in several processes, including intracellular protein transport; peptidyl-serine phosphorylation; and regulation of chromatin assembly or disassembly.