2024年12月25日 · TLK1 (Tousled Like Kinase 1) is a Protein Coding gene. Diseases associated with TLK1 include Pica Disease and Castration-Resistant Prostate Carcinoma. Among its …

Serine/threonine-protein kinase tousled-like 1 is an enzyme that in humans is encoded by the TLK1 gene. [5][6][7] The Tousled-like kinases, first described in Arabidopsis, are nuclear …

TLK1-mediated MK5-S354 phosphorylation drives prostate cancer cell motility and may signify distinct pathologies. CircTLK1 modulates sepsis-induced cardiomyocyte apoptosis via …

2017年7月14日 · The Tousled-like kinases, TLK1 and TLK2, regulate ASF1, a histone H3/H4 chaperone, and likely other substrates, and their activity has been implicated in transcription, …

2018年6月28日 · In humans, the similar TLK1 and TLK2 interact with each other and TLK activity enhances ASF1 histone binding and is inhibited by the DNA damage response, although the …

In addition, the TLKs have been clearly linked to human disease; both TLK1 and TLK2 are frequently amplified in human cancers and TLK2 mutations have been identified in patients …

该基因编码的蛋白质是一种丝氨酸/苏氨酸激酶，可能参与染色质组装的调节。 编码的蛋白质只有在磷酸化时才有活性，这种磷酸化依赖于细胞周期，该蛋白质的最大活性出现在 S 期。 这种 …

2024年4月22日 · Tousled-like kinases 1 and 2 (TLK1 and 2) are cell cycle-regulated serine/threonine kinases that are involved in multiple biological processes. Mutation of TLK1 …

TLK1 Antibody detects endogenous levels of total TLK1. The antibody may cross-react with TLK2. Human, Mouse, Rat. Polyclonal antibodies are produced by immunizing animals with a …

Predicted to enable ATP binding activity and protein serine/threonine kinase activity. Predicted to be involved in several processes, including intracellular protein transport; peptidyl-serine …