The inheritance pattern is complicated in patients with thalassemia because two sets of genes on different chromosomes cooperate to produce hemoglobin. A defect anywhere in this complex can produce thalassemia.

2023年12月20日 · The inheritance pattern of thalassemia is autosomal recessive, meaning that an individual must inherit two copies of the mutated gene, one from each parent, to develop the condition. The mutated genes involved in thalassemia are located on the beta-globin gene cluster on chromosome 11.

Inheritance. There are two main types of thalassemia trait: alpha thalassemia trait and beta thalassemia trait. Individuals who have beta thalassemia trait have one normal beta globin gene and one that is altered such that it makes little or no beta globin. There are subtypes of alpha thalassemia trait.

2009年8月15日 · The thalassemias are a group of inherited hematologic disorders caused by defects in the synthesis of one or more of the hemoglobin chains. Alpha thalassemia is caused by reduced or absent...

2024年9月6日 · Inheritance Pattern. Beta thalassemia is inherited in an autosomal recessive manner, meaning a person must inherit two copies of the mutated gene—one from each parent—to develop the severe form of the disorder. Suppose an …

2022年6月1日 · Thalassemia is inherited, meaning that that you are born with it. Learn about alpha thalassemia and beta thalassemia, the two main types, and how you get the condition.

Thalassemia follows an autosomal recessive inheritance pattern. This means both parents must carry the defective gene for their offspring to develop the disease. Carriers, with only one defective gene, are usually asymptomatic.

Thalassaemia is caused by faulty genes that a child inherits from their parents. It's not caused by anything the parents did before or during the pregnancy, and you cannot catch it from someone who has it. Genes come in pairs. You inherit 1 set from your mother and 1 set from your father.

Alpha thalassaemia is inherited in an autosomal recessive pattern; however, due to the involvement of two genes, inheritance is complex and entirely dependent on the parents’ specific allotypes. If the parents both have the alpha-zero genotypes, one in four of their pregnancies will result in alpha thalassaemia major.

Thalassemia major and thalassemia intermedia are inherited in an autosomal recessive pattern, which means both copies of the gene in each cell have variants. The parents of an individual with an autosomal recessive condition each carry one copy of the altered gene, but they typically do not show signs and symptoms of the condition.