This research focuses on the synthesis of phospho-urodilatin, demonstrating the effectiveness of TBTU as a coupling reagent in segment coupling strategies for peptide synthesis (Mostafavi et al., 1996). Effect of tertiary amine on the carbodiimide-mediated peptide synthesis.:

O- (Benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate | C11H16BF4N5O | CID 2733207 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, safety/hazards/toxicity information, supplier lists, and more.

TBTU was very effective, for instance, in key macrocyclization and coupling steps in the total synthesis of the macrocyclic peptide cyclotheonamide B. These reagents should used in equal molar amounts relative to the carboxylic acid component of the coupling reaction.

2020年10月22日 · 本文主要介绍多肽合成中常用的三种缩合剂 HOBT 、 HBTU 、 TBTU，用于固相多肽合成中的缩合效果。 HOBT 是防止多肽合成中消旋，HBTU、TBTU是多肽合成中强的缩合试剂。 HBTU 和TBTU 是HOBt的加强型，效果更好，反应后生成HOBT。 HBTU的价格便宜一些，100g，350元左右T。 TBTU 贵一些。 缩合效果TBTU 稍微好一些的。 在众多的耦联剂中， …

Methanaminium, N- ( (1H-benzotriazol-1-yloxy) (dimethylamino)methylene)-N-methyl-, tetrafluoroborate (1-)

TBTU is a coupling reagent used for solid-phase peptide synthesis. The compound has been used to study ten different phosphonium and uronium salt-based coupling reagents, which are used to synthesize four peptides.

One of the most popular in situ activation reagents in solid and solution phase peptide synthesis. In addition to having high reactivity, TBTU have also been shown to limit enantiomerization during fragment condensation. CAS: 125700-67-6. Synonym: 2- (1H-Benzotriazole-1-yl)-1,1,3,3-tetramethylaminium tetrafluoroborate.

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2- (1H-苯并三偶氮L-1-基)-1,1,3,3-四甲基脲四氟硼酸酯（TBTU）在乙腈和DMF等有机溶剂中溶解性较好，对水敏感，微溶于水。 不同磺酸与不同肟在50℃下收率良好地合成了一序列磺酸肟酯。 这个方法的好处是反应过程简便、环境无危害和后处理简洁。 偶联试剂，用于固相多肽合成。 ChemicalBook 致力于为化学行业用户提供2- (1H-苯并三偶氮L-1-基)-1,1,3,3-四甲基脲四氟硼酸 …

O- (BENZOTRIAZOL-1-YL)-N, N, N', N'-TETRAMETHYLURONIUM TETRAFLUOROBORATE (TBTU): A NEW REAGENT FOR THE CLEAVAGE OF TETRAHYDROPYRANYL, SILYL AND 4, 4'-D IMETHOXYTRITYL ETHERS. Copper Binding Features of Tropomyosin-Receptor-Kinase-A Fragment: Clue for Neurotrophic Factors and Metals Link.