TAP2 wearables use NFC (Near Field Communication) technology to securely transmit your payment information when you tap your device on a contactless terminal. It's a quick, seamless process that lets you pay instantly without needing your phone or wallet.

2024年12月25日 · TAP2 (Transporter 2, ATP Binding Cassette Subfamily B Member) is a Protein Coding gene. Diseases associated with TAP2 include Mhc Class Ii Deficiency 1 and Mhc Class I Deficiency. Among its related pathways are Antigen processing-Cross presentation and Class I MHC mediated antigen processing and presentation.

TAP1 和 TAP2 基因位于 MHC 位点（见第 6 - 10 节），靠近 PSMB9 和 PSMB8，它们的基础表达水平在应对病毒感染产生的干扰素的作用下进一步提高，这与 MHC I 类以及 蛋白酶体 的β1i、β2i 和β5i 亚基类似。 这种诱导作用致使更多的细胞质内多肽被递送至内质网。 当肽的递送被破坏，如在 TAP 突变细胞中，新合成的 MHC I 类分子会以内质网中部分折叠的状态被保留。 极少数因 TAP1 和 TAP2 缺陷而患有免疫缺陷的人类个体，其细胞表面的 MHC I 类分子也很少，这种状 …

TAP2 is a gene in humans that encodes the protein Antigen peptide transporter 2. [5][6][7] The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes.

近日，由美国迈阿密大学米勒医学院和荷兰莱顿大学医学中心肿瘤内科等研究者发现， 靶向干扰抗原加工相关转运蛋白基因-TAP可以增强肿瘤免疫源性并诱导强烈的抗肿瘤免疫反应，相关研究成果发表在《Nature Communications》。 TAP于1990年被克隆出来，位于 HLA-DQ 与DP之间。 该基因由TAP1和TAP2两个基因组成，分别编码产生抗原加工相关转运蛋白TAP1和TAP2，两者形成二聚体发挥生物学效应，参与MHC-I类抗原的递呈及内源性多肽的胞内转运。 目前针对TAP基因 …

7 小时之前 · tap2 下调保护肺癌细胞免受肿瘤抗原特异性 t 细胞杀伤：将肺癌细胞与肿瘤抗原特异性 cd8 + t 细胞共培养实验表明，tap2 下调显著增加未刺激的肺癌细胞活力，几乎完全阻止肿瘤抗原特异性 t 细胞介导的杀伤。在 tap2 基因敲除细胞中重新引入 tap2 可抑制癌细胞存活 ...

由该基因编码的膜相关蛋白是 ATP 结合盒 (ABC) 转运蛋白超家族的成员。 ABC 蛋白可跨细胞外膜和细胞内膜转运各种分子。 ABC 基因分为七个不同的亚家族 (ABC1、MDR/TAP、MRP、ALD、OABP、GCN20、White) 。 该蛋白是 MDR/TAP 亚家族的成员。 MDR/TAP 亚家族的成员参与了多药耐药性。 该基因位于基因家族成员 ABCB2 的 7 kb 端粒处。 该基因编码的蛋白质参与抗原呈递。 该蛋白质与 ABCB2 形成异二聚体，以便将肽从细胞质转运至内质网。 该基因的突变可 …

5 天之前 · Background Transporter 2, ATP binding cassette (ABC) subfamily B member (TAP2), encodes a protein within the ABC transporter superfamily. TAP2 plays a role in the progression of cancers, such as cervical, breast, and lung cancers. However, the relationship between TAP2 and cancer prognosis, immune cell infiltration, tumor microenvironment, and immunotherapy remains unexplored. Therefore, this ...

1 天前 · Cancer cell selective downregulation of TAP2 is frequent in NSCLC. Using multiplex quantitative immunofluorescence (QIF), we studied the levels and spatial distribution of TAP1 and TAP2 proteins in 819 pre-treatment NSCLCs from 4 independent cohorts of patients treated with chemotherapy and/or surgery (cohort #1, n = 273; cohort #2, n = 255 and cohort #3, n = 152, Tables 1–2) or treated with ...

5 天之前 · TAP2 was identified as a potential predictor of immunotherapy response and screened for potential targeted inhibitors for future therapeutic interventions. Conclusions: Our findings suggest that TAP2 may serve as a promising prognostic marker and immune target in human cancers, warranting further investigation into its role in tumor immunity.