Transient receptor potential cation channel subfamily M (melastatin) member 8 (TRPM8), also known as the cold and menthol receptor 1 (CMR1), is a protein that in humans is encoded by the TRPM8 gene. [5] [6] The TRPM8 channel is the primary molecular transducer of cold somatosensation in humans.

This chapter focuses on TRPM8, describing what was known about cold signaling before the channel was cloned, how TRPM8 was identified as a cold sensor, and what advances have been made in our understanding of the molecular logic for cold sensation since its identification.

Transient Receptor Potential Melastatin 8 (TRPM8) is a member of the TRP ion channel family; its major physiological activator is cold, and it is also activated by “cooling agents” such as menthol. TRPM8 is a well established physiological sensor of environmental cold temperatures.

Transient receptor potential melastatin 8 (TRPM8) channels play a central role in the detection of environmental cold temperatures in the somatosensory system. TRPM8 is found in a subset of unmyelinated (C-type) afferents located in the dorsal root (DRG) and trigeminal ganglion (TG).

2020年9月5日 · The transient receptor potential cation channel subfamily M member 8 (TRPM8) is a nonselective cation channel that controls Ca 2+ homeostasis. It has been proposed to be the predominant thermoreceptor for cellular and behavioral responses to cold stimuli in the transient receptor potential (TRP) channel subfamilies and exploited so far to reach ...

2023年10月18日 · TRPM2 mediates ADP-ribose and reactive oxygen species signalling in neurons, immunocytes and kidney epithelial cells, whereas TRPM8 is a cold-sensing channel that regulates organismal thermal...

2020年9月5日 · Ion channels are important therapeutic targets due to their plethoric involvement in physiological and pathological consequences. The transient receptor potential cation channel subfamily M member 8 (TRPM8) is a nonselective cation …

2020年7月29日 · Menthol in mints elicits coolness sensation by selectively activating TRPM8 channel. Although structures of TRPM8 were determined in the apo and liganded states, the menthol-bounded state is...

2007年5月30日 · The menthol receptor TRPM8 is a strong candidate as a cold transducer, but its physiological importance has been questioned. A study of cold sensitivity in TRPM8 knockout mice has clarified...

2021年8月7日 · The transient receptor potential melastatin subtype 8 (TRPM8) is a cold sensor in humans, activated by low temperatures (>10, <28 °C), but also a polymodal ion channel, stimulated by voltage, pressure, cooling compounds (menthol, icilin), and hyperosmolarity.