2023年5月8日 · The transient receptor potential channel TRPM7 is a master regulator of the organismal balance of divalent cations that plays an essential role in embryonic...

Transient receptor potential cation channel, subfamily M, member 7, also known as TRPM7, is a human gene encoding a protein of the same name.

trpm7通过介导ca⊃2;⁺内流调控tak1-nfκb炎症通路，有效启动炎症因子转录，从而促进脂肪组织炎症，并诱导系统性胰岛素抵抗和其他肥胖并发症的发生。因此，靶向脂肪组织trpm7的治疗方法可能是治疗肥胖、胰岛素抵抗及其相关代谢性并发症的有潜力的新策略。

瞬时电位受体（transient receptor potential，TRP）melastatin亚家族7（TRPM7）是一种包含功能性激酶结构域的非选择性阳离子通道。研究表明，多种肿瘤细胞中TRPM7异常高表达，可通过诱导细胞周期紊乱、调节细胞内阳离子浓度，促进肿瘤细胞生存与增殖。

2024年12月25日 · TRPM7 (Transient Receptor Potential Cation Channel Subfamily M Member 7) is a Protein Coding gene. Diseases associated with TRPM7 include Amyotrophic Lateral Sclerosis-Parkinsonism/Dementia Complex 1 and Hypomagnesemia 1, Intestinal .

trpm7 是一种非选择性阳离子通道，由约1863个氨基酸组成，包括六个跨膜区和一个位于胞内的c端蛋白激酶结构域。 其通道结构允许镁离子（Mg²⁺）、锌离子（Zn²⁺）、钙离子（Ca²⁺）等多种二价阳离子的通过。

2019年4月16日 · The transient receptor potential melastatin-subfamily member 7 (TRPM7) is a ubiquitously expressed chanzyme that possesses an ion channel permeable to the divalent cations Mg 2+, Ca 2+, and Zn 2+, and an α-kinase that phosphorylates downstream substrates. TRPM7 and its homologue TRPM6 have been implicated in a variety of cellular functions and ...

2025年2月8日 · TRPM7 restrains plasmin activity and promotes transforming growth factor-beta1 signaling in primary human lung fibroblasts. TRPM7 Modulates Human Pancreatic Stellate Cell Activation. TRPM7 via calcineurin/NFAT pathway mediates metastasis and chemotherapeutic resistance in head and neck squamous cell carcinoma.

2023年10月18日 · Heterozygous Trpm7 ∆kinase/+ mice are viable but have low Mg 2+ levels in serum, bones and urine, suggesting that TRPM7 has a crucial role in Mg 2+ homeostasis 113.

2025年2月14日 · Our data suggest that TRPM7 is a promising therapeutic target for developing effective prophylactic medications to limit AAA progression.

The channel kinases TRPM6 and TRPM7 are fusion proteins with an ion transport domain and an enzymatically active kinase domain. TRPM7 has been found in every mammalian tissue investigated to date. The two-in-one protein structure, the ubiquitous expression profile, and the protein's unique biophysic …

2024年4月23日 · Nadezhdin et al. solve the structure of TRPM7 in complex with the anticancer drug CCT128930. Combining cryo-EM, functional analysis, and MD simulations, the authors show that CCT128930 binds to a vanilloid-like site and stabilizes the channel in the closed state, revealing the molecular mechanism of selective TRPM7 inhibition.

2018年6月19日 · Liu et al. find that TRPM7 regulates synapse density/plasticity and memory functions across different species and that this regulation depends on the α-kinase domain. These results add to our understanding of TRPM7 functions in the mammalian brain and implicate TRPM7 in the pathologies of some cognitive disorders.

2023年3月6日 · RNA-seq, metabolomics and genetic assay revealed that the TRPM7 channel regulated cellular glycolysis. Deletion of TRPM7 suppressed cancer cell glycolysis and reduced the xenograft tumor burden.

2022年1月1日 · TRPM7 is a non-selective divalent cation channel with an alpha-kinase domain. Corresponding with its broad expression, TRPM7 has a role in a wide range of cell functions, including proliferation, migration, and survival. Growing evidence shows that TRPM7 is also aberrantly expressed in various cancers, including brain cancers.

The transient receptor potential channel TRPM7 is a master regulator of the organismal balance of divalent cations that plays an essential role in embryonic development, immune responses, cell mobility, proliferation, and differentiation. TRPM7 is ...

The enzyme-coupled transient receptor potential channel subfamily M member 7, TRPM7, has been associated with immunity and immune cell signalling. Here, we review the role of this remarkable signalling protein in lymphocyte proliferation, ...

TRPM7 is a fusion protein containing an ion channel permeable to calcium and a serine/threonine protein kinase necessary for the ion channel function. From: Stroke (Seventh Edition), 2022

2021年5月20日 · TRPM7 exerts the facilitating action on VSOR activity first by enhancing molecular expression of LRRC8A mRNA through the mediation of steady-state Ca2+ influx and second by stabilizing the ...

This review summarizes the current understanding of the role of transient receptor potential melastatin-subfamily member 7 (TRPM7) channels in the pathophysiology of neoplastic diseases. The TRPM family represents the largest and most diverse group ...