Transient receptor potential cation channel, subfamily M, member 2, also known as TRPM2, is a protein that in humans is encoded by the TRPM2 gene.

2024年12月25日 · TRPM2 (Transient Receptor Potential Cation Channel Subfamily M Member 2) is a Protein Coding gene. Diseases associated with TRPM2 include Neuroblastoma and Epilepsy. Among its related pathways are Innate Immune System and Ion channel transport. Gene Ontology (GO) annotations related to this gene include hydrolase activity and calcium channel ...

2025年1月16日 · trpm2 是一种由 trpm2 基因编码的离子通道，主要分布于中枢神经系统、免疫细胞、胰腺β细胞以及内皮细胞中。它对细胞内氧化应激和代谢状态非常敏感，是一种与氧化还原信号密切相关的通道。

瞬时受体电位 m2 型（trpm2）离子通道是可渗透钙离子的非选择性阳离子通道，在神经炎症、缺血再灌注脑损伤、神经退行性病变、神经病理性疼痛、癫痫等多种神经系统疾病中发挥重要作用。

2018年4月19日 · Here, we summarize recent evidence on the role of TRPM2 in the central nervous system (CNS) in health and disease and discuss the potential therapeutic implications of targeting TRPM2.

瞬时受体电位 melastatin 2 (TRPM2) 是一种非选择性阳离子通道，表现出 Ca 2+渗透性。 TRPM2通道在多种组织和细胞中表达，可以被多种因素激活，包括内源性配体、Ca 2+ 、活性氧 (ROS) 和温度。

2018年9月24日 · Transient receptor potential melastatin 2 (TRPM2) is a calcium-permeable, non-selective cation channel that has an essential role in diverse...

2023年10月6日 · 为了进一步验证线虫中发现的trpm2通路分子机制是否在帕金森病人中具有保守性，该研究选取了正常人和散发性帕金森病患者来源的诱导多能干细胞 ...

TRPM2 is the second member of the transient receptor potential melastatin-related (TRPM) family of cation channels. The protein is widely expressed including in the brain, immune system, endocrine cells, and endothelia. It embodies both ion channel functionality and enzymatic ADP-ribose (ADPr) hydro …

2023年7月27日 · In this review, we examine the structural and biophysical details of TRPM2, its involvement in neurological and cardiovascular diseases, and its role in inflammation and immune system function. In addition, we provide a comprehensive overview of the current knowledge of TRPM2 signaling pathways in cancer, including its functions in ...