TRPC1 was the first mammalian Transient Receptor Potential channel to be identified. In 1995 it was cloned when the research groups headed by Craig Montell and Lutz Birnbaumer were searching for proteins similar to the TRP channel in Drosophila .

TRPC1 knockdown studies show that inhibition of TRPC1 leads to improved motor performance and rescued medium spiny neurons spines in vitro and in vivo . TRPC channels are also involved in learning and memory.

2024年12月25日 · TRPC1 (Transient Receptor Potential Cation Channel Subfamily C Member 1) is a Protein Coding gene. Diseases associated with TRPC1 include Pyloric Stenosis and T Cell And Nk Cell Immunodeficiency. Among its related pathways are Cardiac conduction and Nervous system development.

TRPC1 and Orai1 form discrete STIM1-gated channels that generate distinct Ca 2+ signals and regulate specific cellular functions. Surface expression of TRPC1 can be modulated by trafficking of the channel to and from the plasma membrane, resulting in changes to the phenotype of TRPC1-mediated current and [Ca 2+ ] i signals.

One known link of TRPC1 to cancer progression is that TRPC1 is a downstream effector of the TGFβ signaling. TGFβ plays a role in modulating a key step in tumor invasion and metastasis, epithelial–mesenchymal transition (EMT).

TRPC1 associates with BK(Ca) channel to form a signal complex in vascular smooth muscle cells. Store-operated Ca(2+) entry in platelets occurs independently of transient receptor potential (TRP) C1. TRPC1 channels regulate directionality of migrating cells.

Transient receptor potential canonical (TRPC) channels constitute a group of receptor-operated calcium-permeable nonselective cation channels of the TRP superfamily. The seven mammalian TRPC members, which can be further divided into four subgroups (TRPC1, TRPC2, TRPC4/5, and TRPC3/6/7) based on the …