2022年10月12日 · Here we report the single-particle cryo-electron microscopy structure of the native transmembrane channel-like protein 1 (TMC-1) mechanosensory transduction complex isolated from Caenorhabditis...

Here we report the single-particle cryo-electron microscopy structure of the native transmembrane channel-like protein 1 (TMC-1) mechanosensory transduction complex isolated from Caenorhabditis elegans.

2024年12月25日 · TMC1 (Transmembrane Channel Like 1) is a Protein Coding gene. Diseases associated with TMC1 include Deafness, Autosomal Dominant 36 and Deafness, Autosomal Recessive 7. Among its related pathways are Sensory processing of sound and Olfactory Signaling Pathway.

Transmembrane channel-like protein 1 is a protein that in humans is encoded by the TMC1 gene. [5][6][7] TMC1 contains six transmembrane domains with both the C and N termini on the endoplasmic side of the membrane, as well as a large loop between domains 4 and 5.

该项研究成功突破了哺乳动物tmc1和tmc2 (tmc1/2)蛋白在细胞系内异源表达无法定位在细胞膜上的难题，证明了人类tmc1/2是机械力门控离子通道，提供了其在毛细胞上作为听觉受体的决定性证据，揭开了感觉神经生物学领域内长期悬而未决的谜团。

2022年8月3日 · Having uncovered evidence that TMC1 serves a unique and essential role in regulating membrane homeostasis from experiments where we compared organ of Corti explants obtained from Tmc1 −/− and Tmc2 −/− mice, we reasoned that Tmc1 −/− mice with the Tmc1-cherry transgene ectopically inserted into the X chromosome would provide a ...

2024年12月17日 · 耳聋相关的tmc1突变改变了tmc1的逆转电位，表明tmc1/2是成孔的机械转导通道。 总之，该研究提供了证据，证明人类TMC1/2是孔隙形成，机械激活的离子通道，支持它们在毛细胞中作为机械转导通道的作用。

2025年2月17日 · 基于解析的高分辨率TMC1 CR1-CIB2结构和AlphaFold-Multimer的预测辅助，研究团队构建了全长的哺乳动物TMC1-CIB2复合体模型，并利用长时间分子动力学模拟揭示了钙离子诱导的复合体构象变化过程。

2016年7月7日 · Transmembrane channel-like protein isoform-1 (TMC1) has emerged over the past five years as a prime contender for the mechano-electrical transducer (MET) channel in hair cells of the inner ear.

2025年2月25日 · We have reported several notable findings: 1) A Fyn lipidation tag enhances cell-surface expression of mouse and human TMC1/2, helping to overcome longstanding technical challenges in characterizing TMC1/2 in heterologous cells; 2) Full-length mTMC1/2, when expressed alone, function as MS channels in whole-cell patch-clamp assays, supporting ...