Structures of the TMC-1 complex illuminate mechanosensory …
2022年10月12日 · Here we report the single-particle cryo-electron microscopy structure of the native transmembrane channel-like protein 1 (TMC-1) mechanosensory transduction complex …
Structures of the TMC-1 complex illuminate mechanosensory
Here we report the single-particle cryo-electron microscopy structure of the native transmembrane channel-like protein 1 (TMC-1) mechanosensory transduction complex isolated from …
TMC1 Gene - GeneCards | TMC1 Protein | TMC1 Antibody
2024年12月25日 · TMC1 (Transmembrane Channel Like 1) is a Protein Coding gene. Diseases associated with TMC1 include Deafness, Autosomal Dominant 36 and Deafness, Autosomal …
TMC1 - Wikipedia
Transmembrane channel-like protein 1 is a protein that in humans is encoded by the TMC1 gene. [5][6][7] TMC1 contains six transmembrane domains with both the C and N termini on the …
首都医学科学创新中心-Neuron｜闫致强团队揭示人类TMC1和TMC…
该项研究成功突破了哺乳动物tmc1和tmc2 (tmc1/2)蛋白在细胞系内异源表达无法定位在细胞膜上的难题，证明了人类tmc1/2是机械力门控离子通道，提供了其在毛细胞上作为听觉受体的决定性 …
Regulation of membrane homeostasis by TMC1 mechanoelectrical ...
2022年8月3日 · Having uncovered evidence that TMC1 serves a unique and essential role in regulating membrane homeostasis from experiments where we compared organ of Corti …
【前沿进展】Cell子刊 | 深圳湾实验室闫致强团队研究表明人体TMC1 …
2024年12月17日 · 耳聋相关的tmc1突变改变了tmc1的逆转电位，表明tmc1/2是成孔的机械转导通道。 总之，该研究提供了证据，证明人类TMC1/2是孔隙形成，机械激活的离子通道，支持它 …
上海交大陆青课题组与合作者报道耳聋基因TMC1遗传异质性致病机制和钙调控TMC1 …
2025年2月17日 · 基于解析的高分辨率TMC1 CR1-CIB2结构和AlphaFold-Multimer的预测辅助，研究团队构建了全长的哺乳动物TMC1-CIB2复合体模型，并利用长时间分子动力学模拟揭示了 …
Is TMC1 the Hair Cell Mechanotransducer Channel? - PMC
2016年7月7日 · Transmembrane channel-like protein isoform-1 (TMC1) has emerged over the past five years as a prime contender for the mechano-electrical transducer (MET) channel in …
Ectopic mouse TMC1 and TMC2 alone form mechanosensitive …
2025年2月25日 · We have reported several notable findings: 1) A Fyn lipidation tag enhances cell-surface expression of mouse and human TMC1/2, helping to overcome longstanding …