Transmembrane channel-like protein 1 is a protein that in humans is encoded by the TMC1 gene. [5][6][7] TMC1 contains six transmembrane domains with both the C and N termini on the endoplasmic side of the membrane, as well as a large loop between domains 4 and 5.

2022年10月12日 · Here we report the single-particle cryo-electron microscopy structure of the native transmembrane channel-like protein 1 (TMC-1) mechanosensory transduction complex isolated from Caenorhabditis...

2025年2月25日 · Here, our study unveils CIB2/3’s role as a calcium sensor in its interaction with TMC1. Utilizing X-ray crystallography, we elucidate the high-resolution structure of the mammalian CIB2-TMC1...

2025年2月5日 · Mammalian transmembrane channel-like proteins 1 and 2 (TMC1 and TMC2) have emerged as very promising candidate mechanotransduction channels in hair cells. However, controversy persists because the heterogeneously expressed TMC1/2 in cultured cells lack evidence of mechanical gating, primarily due to …

2025年2月25日 · Recently, TMC1 and TMC2 (TMC1/2) have emerged as the pore-forming subunit of the MT channel. However, the functional study of TMC1/2 in heterologous cells has been challenging due to their lack of plasmalemmal expression.

2024年12月25日 · TMC1 (Transmembrane Channel Like 1) is a Protein Coding gene. Diseases associated with TMC1 include Deafness, Autosomal Dominant 36 and Deafness, Autosomal Recessive 7. Among its related pathways are Sensory processing of sound and Olfactory Signaling Pathway.

TMC1 encodes a protein required for the normal function of mechanically-activated channels that enable sensory transduction in auditory and vestibular hair cells. TMC1 protein is localized at the tips of the hair cell stereocilia, the site of conventional mechanotransduction.

Mammalian transmembrane channel-like proteins 1 and 2 (TMC1 and TMC2) have emerged as very promising candidate mechanotransduction channels in hair cells. However, controversy persists because the heterogeneously expressed TMC1/2 in cultured cells lack evidence of mechanical gating, primarily due to their absence from the plasma membrane.

2025年2月8日 · TMC1 has been identified as the causative gene in a six-generation Chinese family with autosomal dominant hearing loss. The first mutation in the TMC1 gene in the Moroccan population causing non-syndromic hearing loss.

2019年1月22日 · Here, the authors use a synthetic AAV to replace TMC1 and 2 in the inner ear and show restoration of cochlear and vestibular function, of neuronal reponses in the auditory cortex and of hearing...