Transforming growth factor, beta receptor II (70/80kDa) is a TGF beta receptor. TGFBR2 is its human gene. It is a tumor suppressor gene. [5] This gene encodes a member of the serine/threonine protein kinase family and the TGFB receptor subfamily.

2024年12月25日 · TGFBR2 (Transforming Growth Factor Beta Receptor 2) is a Protein Coding gene. Diseases associated with TGFBR2 include Loeys-Dietz Syndrome 2 and Esophageal Cancer. Among its related pathways are Loss of Function of TGFBR2 in Cancer and TGF-beta receptor signaling activates SMADs.

The TGFBR2 gene provides instructions for making a protein called transforming growth factor-beta (TGF-β) receptor type 2. This receptor transmits signals from the cell surface into the cell through a process called signal transduction.

Results show that TGFbR2 expression decreases in human gastric cancer (GC) tissue specimens and indicate that the expression of TGFbR2 is mainly dependent on post-transcriptional regulators in GC through miR-155 binding to the 3'-UTR of its mRNA.

2021年4月29日 · Transforming growth factor β (TGFβ) signaling plays critical roles in reproductive development and function. TGFβ ligands signal through the TGFβ receptor type 2 (TGFBR2)/TGFBR1 complex.

2024年9月8日 · Proinflammatory plasticity towards Th17 paradigm of regulatory T cells consistent with elevated prevalence of TGFBR2 variants in elderly patients with primary immune thrombocytopenia.

In a mouse model of AD, reduced neuronal TGFBR2 signaling resulted in accelerated age-dependent neurodegeneration and promoted beta-amyloid accumulation and dendritic loss. Reduced TGFBR2 signaling in neuroblastoma cell cultures resulted in increased levels of secreted beta-amyloid and soluble APP (104760).

2020年10月21日 · Here we show that depletion of transforming growth factor-β receptor 2 (TGFBR2) in CD4 + T cells, but not CD8 + T cells, halts cancer progression as a result of tissue healing and...

Focusing on the receptors in events in and beyond TGF-β signaling, we review the membrane trafficking of TGFBRs, the kinase activity of TGFBR1 and 2, the direct interactions between TGFBR2 and other receptors, and the novel roles of TGFBR3.

2025年1月30日 · Our comprehensive genetic analysis suggested that the p.Glu335_Tyr336delinsAsp variant of TGFBR2 caused aberrant TGF-β signaling and contributed to LDS in the patient.