2024年12月25日 · TGFB3 (Transforming Growth Factor Beta 3) is a Protein Coding gene. Diseases associated with TGFB3 include Loeys-Dietz Syndrome 5 and Arrhythmogenic Right Ventricular Dysplasia, Familial, 1. Among its related pathways are Apoptotic Pathways in Synovial Fibroblasts and MIF Mediated Glucocorticoid Regulation.

转化生长因子 TGF-β的名称来源于其转化活性，根据不同的细胞系，当与EGF一起施用或不需要添加EGF时，可诱导细胞锚定非依赖性生长。 最先被鉴定并分离的两种转化生长因子是TGF-α和-β（β1）。 但是TGF-α属于 EGF家族，与EGF受体结合，而TGF-β在结构上与TGF-α不同。 当时区分这两种细胞因子的最显著特征是，TGF-β是一种25kD的 二硫键 链接的二聚体，经还原剂（例如β-巯基乙醇）处理后，在凝胶上还原为12.5kD的条带，而TGF-α是一种较小的单体蛋白。 所 …

Transforming growth factor beta-3 is a protein that in humans is encoded by the TGFB3 gene. [5] [6] It is a type of protein, known as a cytokine, which is involved in cell differentiation, embryogenesis and development.

TGF-β3 is a more potent inhibitor of DNA synthesis in human keratinocytes compared to TGF-β1 and TGF-β2. TGF-β3 mRNA is expressed in lymphocytes such as CD4 + T cells, CD8 + T cells, γδT cells, and B cells. TGF-β3 has the potential to regulate systemic autoimmune diseases by inhibiting B cells.

TGF-β的命名是根据这种细胞因子能使正常的成纤维细胞的表型发生转化，即在表皮生长因子（EGF）同时存在的条件下，改变成纤维细胞贴壁生长特性而获得在琼脂中生长的能力，并失去生长中密度信赖的抑制作用而来。 TGF-β信号在早期胚胎发育与组织器官形成、免疫监督、组织修复与成体稳态平衡中发挥重要作用。 TGF-β信号转导异常则可能导致多种疾病的发生，比如胚胎发育异常、肿瘤、组织纤维化、心血管疾病和免疫性疾病等。

The TGFB3 gene provides instructions for producing a protein called transforming growth factor beta-3 (TGFβ-3). This protein is found throughout the body and is required for development before birth and throughout life. To carry out its functions, TGFβ-3 attaches (binds) to receptor proteins on the surface of cells.

transforming growth factor beta-3 proprotein, prepro-transforming growth factor beta-3. TGF-beta3 from fibroblasts promotes necrotising sialometaplasia by suppressing salivary gland cell proliferation and inducing squamous metaplasia.

2025年1月4日 · Title: TGFB3 gene mutation associated with mandibular coronoid process hyperplasia: a family investigation. TGF-beta3 in differentiation and function of Tph-like cells and its relevance to disease activity in patients with systemic lupus erythematosus.

该基因编码 TGF-β (转化生长因子-β) 蛋白质超家族的分泌配体。 该家族的配体结合各种 TGF-β 受体，导致调节基因表达的 SMAD 家族转录因子的募集和激活。 编码的前原蛋白经过蛋白水解处理以生成潜伏相关肽 (LAP) 和成熟肽，并且以由成熟肽同二聚体、LAP 同二聚体和潜伏 TGF-β 结合蛋白组成的潜伏形式被发现，或者以仅由成熟肽同源二聚体组成的活性形式存在。 成熟肽还可以与其他 TGF-β 家族成员形成异二聚体。 这种蛋白质参与胚胎发生和细胞分化，并可能在伤口愈 …

2015年7月16日 · Nawshad and Hay (2003) showed that Tgfb3 brought about palatal seam EMT in mice by stimulating expression of Lef1 in medial edge epithelial cells. Tgfb3 activated Lef1 in the absence of beta-catenin (CTNNB1; 116806) via nuclear phospho-Smad2 and Smad4 .