The TET2 gene provides instructions for making a protein whose function is unknown. Based on the function of similar proteins, researchers believe the TET2 protein is involved in regulating the process of transcription, which is the first step in protein production.

2024年12月25日 · TET2 (Tet Methylcytosine Dioxygenase 2) is a Protein Coding gene. Diseases associated with TET2 include Immunodeficiency 75 With Lymphoproliferation and Myelodysplastic Syndrome. Among its related pathways are Meiosis and Gene expression (Transcription).

2024年11月9日 · TET2 is a critical gene that regulates DNA methylation, encoding a dioxygenase protein that plays a vital role in the regulation of genomic methylation and other epigenetic modifications, as well as in hematopoiesis. Mutations in TET2 are present in 7%–28% of adult acute myeloid leukemia (AML) patients.

2023年8月11日 · Ten-eleven translocation (TET) family proteins (TETs), specifically, TET1, TET2 and TET3, can modify DNA by oxidizing 5-methylcytosine (5mC) iteratively to yield 5-hydroxymethylcytosine (5hmC), 5...

TET2, a member of ten-eleven translocation (TET) family as α-ketoglutarate- and Fe 2+ -dependent dioxygenase catalyzing the iterative oxidation of 5-methylcytosine (5mC), has been widely recognized to be an important regulator for normal hematopoiesis especially myelopoiesis.

2020年11月12日 · In various mammalian cells, Tet methylcytosine dioxygenase 2 (Tet2) catalyzes oxygen transfer to a methyl group of 5-methylcytosine (5mC), yielding 5-hydroxymethylcytocine (5hmC). Tet2...

2009年5月28日 · We analyzed the consequences of deletions or mutations in TET2 with the use of in vitro clonal assays and transplantation of human tumor cells into mice.

2025年2月8日 · TET2 inhibits the proliferation and metastasis of lung adenocarcinoma cells via activation of the cGAS-STING signalling pathway. Nuclear localization of TET2 requires beta-catenin activation and correlates with favourable prognosis in colorectal cancer. TET2-mediated mRNA demethylation regulates leukemia stem cell homing and self-renewal.

5 天之前 · Briefly, Tet2 WT or Tet2 KO cells were seeded at a density of 2x10 5 cells/mL in a well in a 24-well TC-treated tissue culture plate (Falcon, #353047) and infected with 50uL of viral supernatant ...

TET proteins, such as TET2, play key roles in the regulation of DNA-methylation status by oxidizing 5-methylcytosine (5mC) to generate 5-hydroxymethylcytosine (5hmC), which can both serve as a stable epigenetic mark and participate in active demethylation (Guallar et al., 2018).