Tbr1 is a protein, called a transcription factor, that binds to DNA and regulates the transcription of genes into mRNA. It is expressed in postmitotic projection neurons and is critical for normal …

2024年12月25日 · TBR1 (T-Box Brain Transcription Factor 1) is a Protein Coding gene. Diseases associated with TBR1 include Intellectual Developmental Disorder With Autism And Speech …

2025年2月8日 · We performed detailed functional analyses of de novo missense TBR1 variants found in the T-box of utism spectrum disorders cases, assessing many aspects of protein …

2018年9月24日 · We performed detailed functional analyses of de novo missense TBR1 variants found in the T-box of ASD cases, assessing many aspects of protein function, including …

关于 tbr1 Cytogenetic location: 2q24.2 Genomic coordinates (GRCh38): 2:161,416,297-161,425,870 (from NCBI) This gene has 6 transcripts (splice variants), 254 orthologues, 16 …

A paper in this issue of Neuron describes the work from Rubenstein and colleagues on how the loss of the Tbr1 gene severely disrupts this process and highlights its critical role in cortical …

2024年12月15日 · This website was built by parents with children diagnosed with TBR1 syndrome or TBR1 related disorder, also called IDDAS (Intellectual Development Disorder with Autism …

2020年1月31日 · TBR1, a T-box transcription factor expressed in the cerebral cortex, regulates the expression of several candidate genes for autism spectrum disorders (ASD).

T-brain-1 (TBR1) is a brain-specific T-box transcription factor. In 1995, Tbr1 was first identified from a subtractive hybridization that compared mouse embryonic and adult telencephalons. …

The TBR1 gene encodes a neuron-specific transcription factor of the T-box family that plays a central role during cortical neurogenesis (summary by Vegas et al., 2018 and McDermott et …