TBK1 (TANK-binding kinase 1) is an enzyme with kinase activity. Specifically, it is a serine / threonine protein kinase. [5] It is encoded by the TBK1 gene in humans. [6] This kinase is mainly known for its role in innate immunity antiviral response. However, TBK1 also regulates cell proliferation, apoptosis, autophagy, and anti-tumor immunity. [5]

2020年7月10日 · TANK-binding kinase 1 (TBK1), along with its close analogue I-kappa-B kinase epsilon, is a central kinase in innate adaptor complexes linking activation of PRRs to mobilization of transcriptional factors that transcribe proinflammatory cytokines, type I interferon (IFN-α/β), and myriads interferon stimulated genes.

2024年12月25日 · TBK1 (TANK Binding Kinase 1) is a Protein Coding gene. Diseases associated with TBK1 include Encephalopathy, Acute, Infection-Induced 8 and Frontotemporal Dementia And/Or Amyotrophic Lateral Sclerosis 4. Among its related pathways are Toll Like Receptor 7/8 (TLR7/8) Cascade and Cytosolic sensors of pathogen-associated DNA.

2023年1月12日 · Using a suite of genetic and pharmacological tools across multiple experimental model systems, we confirm a role for TBK1 as an immune-evasion gene. Targeting TBK1 enhances responses to PD-1...

2025年3月7日 · TBK1 (TANK binding kinase 1) and IKKε [inhibitor of nuclear factor κ B (NF-K B) kinase subunit ε] are two central kinases in the regulation of several cellular processes and immune pathways including autophagy, metabolism, antiviral immune responses, and cell death pathways.They are two highly related kinases, and the loss of one is often compensated by …

Abstract. TANK-binding kinase 1 (TBK1) is a key signaling kinase involved in innate immune and inflammatory responses. TBK1 drives immune cells to participate in the inflammatory response by activating the NF-κB and interferon regulatory factor signaling pathways in immune cells, promoting the expression of pro-inflammatory genes, and regulating immune cell function.

2021年8月6日 · Homozygous LoF TBK1 produces systemic autoinflammation, not overt viral disease. Expressed but inactive TBK1 inhibits IFN-I induction more than no TBK1. Autoinflammation is driven by TNF-induced cell death caused by dysregulated RIPK1. Treatment with anti-TNF resolves clinical disease.

2024年3月21日 · TANK-binding kinase 1 (TBK1) is a versatile serine/threonine protein kinase with established roles in innate immunity, metabolism, autophagy, cell death, and inflammation.

2021年10月1日 · In this review, we highlight the diverse biological functions of TBK1 and summarize the promising small-molecule inhibitors of TBK1 that have the potential to be developed as therapeutic candidates. The inhibitor-kappaB kinase (IKK) family contains canonical and non-canonical IKK kinases.

2018年1月1日 · Also known as NAK (NF-κB-activating kinase) or T2K (TRAF2-associated kinase), TBK1 is a ubiquitously expressed 729-amino-acid serine/threonine kinase that is a noncanonical IκB kinase family member, targeting the transcription factors IRF3 and IRF7 in the type I interferon response.