2021年10月21日 · Bitter taste-sensing type 2 receptors (TAS2Rs or T2Rs), belonging to the subgroup of family A G-protein coupled receptors (GPCRs), are of crucial importance in the perception of bitterness.

In vertebrates, bitter perception is initiated by TAS2Rs, a family of G protein-coupled receptors expressed on the surface of taste buds. There, oriented toward the interior of the mouth, they monitor the contents of foods, drinks and other substances as they are ingested.

2019年12月2日 · Here we evaluated the role of the bitter receptor TAS2R38 in attainment of longevity, since it has been widely associated with individual differences in taste perception, food preferences, diet,...

2023年6月7日 · Among the four different cell types housed in taste buds, the type II cells express the G protein-coupled receptors (GPCRs) mediating sweet, umami and bitter taste 3. Taste GPCRs are divided into...

TAS2R receptors detect ingested bitter compounds such as toxic plant alkaloids, while TAS1R detects sugars such as glucose and sucrose. There are about 25 functional TAS2R genes that code bitter taste receptor proteins, while there are only three TAS1R genes that code sweet and umami taste receptors [2,9] .

2024年5月22日 · Of the 25 human TAS2Rs, TAS2R14 is a prominent member expressed not only in gustatory tissues but also in extra-oral organs 12, such as heart 13 and airway smooth muscle 3, in which its...

2021年10月21日 · Bitter taste-sensing type 2 receptors (TAS2Rs or T2Rs), belonging to the subgroup of family A G-protein coupled receptors (GPCRs), are of crucial importance in the perception of bitterness.

2022年2月1日 · Bitter taste receptors (taste 2 receptors, TAS2Rs) serve as warning sensors in the lingual system against the ingestion of potentially poisonous food. Here, we investigated the functional role of TAS2Rs in the human gut and focused on their potential to trigger an additional host defense pathway in the intestine.

Bitter-taste receptors (TAS2Rs) are involved in airway relaxation but are also expressed in human blood leukocytes. We studied TAS2R expression and the effects of TAS2R agonists on the lipopolysaccharide (LPS)-induced cytokine release in human lung ...

2025年1月31日 · TAS2Rs are a family of G protein-coupled receptors that function as bitter taste receptors in vertebrates. Mammalian TAS2Rs have historically garnered the most attention, leading to our understanding of their roles in taste perception relevant to …