Targeting advanced prostate cancer with STEAP1 chimeric antigen ...
2023年4月11日 · Here, we report broad expression of STEAP1 relative to prostate-specific membrane antigen (PSMA) in lethal metastatic prostate cancers and the development of a …
Targeting STEAP1 as an anticancer strategy - Frontiers
2023年10月15日 · STEAP1 is now drawing attention as a promising therapeutic target because of its tumor specificity and membrane-bound localization. The clinical efficacy of an antibody …
STEAP1 - Wikipedia
Metalloreductase STEAP1 is an enzyme that in humans is encoded by the STEAP1 gene. [5] This gene is predominantly expressed in prostate tissue, and is found to be upregulated in multiple …
Xaluritamig, a STEAP1 × CD3 XmAb 2+1 Immune Therapy for
2024年1月12日 · Xaluritamig (AMG 509) is a six-transmembrane epithelial antigen of the prostate 1 (STEAP1)-targeted T-cell engager designed to facilitate lysis of STEAP1-expressing cancer …
• STEAP1 is a membrane protein that is overexpressed in > 80% of prostate cancers, representing an attractive target for treating mCRPC 11-13 • Several modalities are being …
STEAP Proteins: From Structure to Applications in Cancer Therapy
2012年5月1日 · STEAP1 actively increases intra- and intercellular communication through the modulation of Na +, Ca 2+, and K + concentration, as well as the concentration of small …
Expression of STEAP1 and STEAP1B in prostate cell lines, and the ...
STEAP1 and STEAP1B gene share high homology and are differentially expressed in human prostate cell lines. A detailed in silico analysis allowed to compare the genomic organization of …
STEAP1 as a Potential Target for New Therapies in Prostate Cancer
The expression of STEAP1 is associated with higher Gleason scores and a worse prognosis in prostate cancer patients. STEAP1 is only minimally expressed in normal tissues, including the …
STEAP1–4 (Six-Transmembrane Epithelial Antigen of the Prostate …
STEAP1, in particular, is highly expressed on the plasma membrane of prostate cancer cells and has received significant attention as a potential therapeutic target. This review highlights what …
STEAP1 STEAP family member 1 [ (human)] - National Center for ...
2025年1月4日 · STEAP1 facilitates metastasis and epithelial-mesenchymal transition of lung adenocarcinoma via the JAK2/STAT3 signaling pathway. Cryo-electron microscopy structure …