Somatostatin receptor type 4 is a protein that in humans is encoded by the SSTR4 gene. [5][6] Somatostatin acts at many sites to inhibit the release of many hormones and other secretory proteins. The biologic effects of somatostatin are probably mediated by a family of G protein-coupled receptors that are expressed in a tissue-specific manner.

生长抑素的生物学作用可能是由以组织特异性方式表达的 G 蛋白偶联受体家族介导的。 SSTR4 是具有七个跨膜区段的受体超家族的成员，并且在胎儿和成人脑和肺中以最高水平表达。 [RefSeq 提供，2008 年 7 月] Somatostatin acts at many sites to inhibit the release of many Hormones and Other secretory proteins.

2019年12月11日 · Somatostatin released from the capsaicin-sensitive sensory nerves mediates analgesic and anti-inflammatory effects via the somatostatin sst 4 receptor without endocrine actions. Therefore, sst 4 is considered to be a novel target for drug development in pain including chronic neuropathy, which is an emerging unmet medical need.

2024年5月6日 · SSTR4. Studies have determined that somatostatin receptor subtype 4 (SSTR4) plays an important role in controlling several brain functions based on the following observations: • Experimental studies using bacTRAP technology have indicated that SSTR4 is highly expressed in areas of the brain involved in learning and memory processes

sstr4是sstr(生长抑素受体)的五种亚型之一，在中枢神经系统中高度表达并介导有效的镇痛和抗炎作用。 作为一种全新的疼痛靶点，SSTR4激动剂有望用于治疗慢性神经性疼痛、炎症性疼痛和混合性疼痛。

Stimulation of somatostatin receptor 4 (SSTR4) inhibits nociception in animals, and SSTR4 knockout mice have heightened responses to painful stimuli compared with wild-

2024年12月25日 · SSTR4 (Somatostatin Receptor 4) is a Protein Coding gene. Diseases associated with SSTR4 include Prolactinoma and Sotos Syndrome. Among its related pathways are Class A/1 (Rhodopsin-like receptors) and GPCR downstream signalling.

SSTR4 is a member of the superfamily of receptors having seven transmembrane segments and is expressed in highest levels in fetal and adult brain and lung. [provided by RefSeq, Jul 2008] somatostatin receptor type 4, G-protein coupled receptor.

Somatostatin is an important mood and pain-regulating neuropeptide, which exerts analgesic, anti-inflammatory, and antidepressant effects via its Gi protein-coupled receptor subtype 4 (SST4) without endocrine actions. SST4 is suggested to be a unique novel drug target for chronic neuropathic pain, and depression, as a common comorbidity.

2013年5月17日 · According to recent studies, somatostatin alleviates pain even in cases when opioids fail and has an important role in neuromodulations such as pain control, presumably via SSTR4 mediation. Additional studies showed that mice has become prone to sustained pain and devoid of analgesic effect in the absence of SSTR4.