2024年12月25日 · SOX1 (SRY-Box Transcription Factor 1) is a Protein Coding gene. Diseases associated with SOX1 include Lambert-Eaton Myasthenic Syndrome and Bilateral Hypoactive Labyrinth. Among its related pathways are Gastrulation and ERK Signaling.

SOX1 is a gene that encodes a transcription factor with a HMG-box (high mobility group) DNA-binding domain and functions primarily in neurogenesis. SOX1, SOX2 and SOX3, members of the SOX gene family (specifically the SOXB1 group), contain transcription factors related to SRY, the testis-determining factor.

SOX1 is one of the earliest TFs expressed in cells committed to the neural fate. Its expression correlates with the formation of neural plate, while down-regulation of Sox1 expression in the developing neural tube correlates with the exit of cells from mitosis (Pevny et al., 1998).

Anti-Sry-like high mobility group box (SOX) 1 antibodies (abs) are partly characterized onconeural autoantibodies (autoabs) due to their correlation with neoplastic diseases. Anti-SOX1 abs are associated with various clinical manifestations, including Lambert-Eaton myasthenic syndrome (LEMS) and paraneoplastic cerebellar degeneration (PCD).

Data show that high levels of SRY-box transcription factor 1 (SOX1) observed in a subset of patients correlate with lower overall survival, and suggest SOX1 as a potential target in the glioma stem cells (GSCs) population in glioblastoma.

SOX1 plays many roles in embryogenesis, oncogenesis, and male sex determination, and can promote glioma stem cell proliferation, invasion, and migration due to its high expression in glioblastoma cells.

We demonstrate a role for SOX1 in neural determination and differentiation using an inducible expression P19 cell system as an in vitro model of neurogenesis. Misexpression of SOX1 can substitute for the requirement of retinoic acid to impart …

Objective: To describe the clinical associations of SOX1 antibodies (SOX1-Abs), determine the accuracy of various detection techniques, and propose laboratory criteria to identify definite paraneoplastic neurological syndromes (PNS) associated with SOX1-Abs.

2004年5月15日 · Sox1 binds directly to the Hes1 promoter and suppresses Hes1 transcription, thus attenuating Notch signaling. Sox1 also binds to β-catenin and suppresses β-catenin-mediated TCF/LEF signaling, thus potentially attenuating the wnt signaling pathway. The C-terminus of Sox1 is required for both of these interactions.

First, most Sox factors are expressed in multiple types of stem/progenitor cell types or tissues. Second, many Sox factors act redundantly in the maintenance of stem cells (e.g., Sox1, Sox2, Sox3, Sox9 in NPCs), which may explain why certain Sox gene knockouts do not exhibit obvious phenotypes due to compensation by other Sox factors.