2024年12月25日 · SLC7A5 (Solute Carrier Family 7 Member 5) is a Protein Coding gene. Diseases associated with SLC7A5 include Respiratory System Cancer and Lysinuric Protein Intolerance. Among its related pathways are Transport of inorganic cations/anions and amino acids/oligopeptides and Blood-Brain Barrier: Anatomy.

2021年1月7日 · We show that concomitant mutation of Apc and Kras in the mouse intestinal epithelium profoundly rewires metabolism, increasing glutamine consumption. Furthermore, SLC7A5, a glutamine antiporter,...

2020年11月4日 · Pathogenic mutations in the solute carrier family 7 member 5 (SLC7A5) gene, which encodes an amino acid transporter cause microcephaly and seizures, yet the mechanisms responsible for these phenotypes are unclear.

We show that concomitant mutation of Apc and Kras in the mouse intestinal epithelium profoundly rewires metabolism, increasing glutamine consumption. Furthermore, SLC7A5, a glutamine antiporter, is critical for colorectal tumorigenesis in models of both early- …

2025年1月28日 · SLC7A5 is an antiporter that can export glutamine, 40 and intracellular glutamine levels were increased in SLC7A5 KO cell lines in arginine-free media (Figures S2D and S2E). We next quantified the effects of SLC7A5 deletion on the total consumption of citrulline in arginine-free media.

Distinct from glucose transporters, amino acid transporters include ones whose expression is specific to cancer cells. For example, LAT1 (SLC7A5) displays protein expression mostly limited to the plasma membrane of cancer cells.

Study shows that the solute carrier transporter 7a5 (SLC7A5), a large neutral amino acid transporter localized at the blood brain barrier (BBB), has an essential role in maintaining normal levels of brain branched-chain amino acids; also identified several patients with autistic traits and motor delay carrying deleterious homozygous mutations ...

Here, we show that the amino acid transporter Slc7a5 / Lat1 is highly expressed in tissues undergoing morphogenesis and that Slc7a5 ‐null mouse embryos have profound neural and limb bud outgrowth defects.

SLC7A5, known as LAT1, belongs to the APC superfamily and forms a heterodimeric amino acid transporter interacting with the glycoprotein CD98 (SLC3A2) through a conserved disulfide. The complex is responsible for uptake of essential amino acids in ...

Slc7a5 is an evolutionarily conserved transporter that facilitates cellular uptake of neutral amino acids (14–16). Slc7a5 is associated with Slc3a2 in a heteromeric complex and together function as an amino acid antiporter (17). Notably, Slc7a5 transports leucine into cells (14, 17).