Sfpi1是髓系发育中的先驱转录调节因子。 Sfpi1的表达差异决定了Ly6嵌合细胞向iNOS+巨噬细胞或单核细胞来源的树突状细胞的分化。 巨噬细胞分类

2025年2月8日 · Data indicate that cultured Sfpi1(BN/BN) cells expressed elevated messenger RNA transcript and protein levels of E2F1, an important regulator of cell cycle entry. Spi-1 inhibits mitochondrial apoptosis in vitro and in vivo through the transcriptional repression of Bim, a proapoptotic factor.

2024年12月25日 · SPI1 (Spi-1 Proto-Oncogene) is a Protein Coding gene. Diseases associated with SPI1 include Agammaglobulinemia 10, Autosomal Dominant and Autosomal Agammaglobulinemia. Among its related pathways are Gene expression (Transcription) and Assembly of the pre-replicative complex.

2009年7月30日 · Our findings indicate that GATA factors act sequentially to regulate lineage determination during hematopoiesis, in part by exerting variable repressive effects at the PU.1/Sfpi1 locus. GATA-1 and PU.1 are essential hematopoietic transcription factors that control erythromegakaryocytic and myelolymphoid differentiation, respectively.

2010年6月3日 · PU.1 is encoded by the Sfpi1 (Spi-1) gene and produces a protein consisting of 272 amino acids (predicted MW of 31 kDa), and is related to the Spi-B and Spi-C Ets-family factors (both...

Hematopoiesis is coordinated by a complex regulatory network of transcription factors and among them PU.1 (Spi1, Sfpi1) represents a key molecule. This review summarizes the indispensable requirement of PU.1 during hematopoietic cell fate decisions and how the function of PU.1 can be modulated by pr …

2009年7月30日 · Specifically, we show that restoration of GATA-1 function in the Gata1 − erythromegakaryocytic cell line G1ME induces down-regulation of PU.1/Sfpi1 mRNA and protein coincident with physical binding of GATA-1 to the PU.1/Sfpi1 …

PU.1 (encoded by the gene Sfpi1) regulates numerous genes within the myeloid and lymphoid lineages, including those encoding the developmentally important cytokine receptors, macrophage colony stimulating factor receptor (M-CSFR), granulocyte-macrophage colony stimulating factor receptor (GM-CSFR), and the interleukin 7 receptor (IL-7R, reviewed...

The transcription factor PU.1, encoded by the murine Sfpi1 gene (SPI1 in humans), is a member of the Ets transcription factor family and plays a vital role in commitment and maturation of the myeloid and lymphoid lineages. Murine studies directly link primary acute myeloid leukaemia (AML) and decrea …

2009年7月7日 · We used immortalized Gata1 − erythromegakaryocytic progenitor cells to study how PU.1/Sfpi1 expression is regulated by GATA-1 and GATA-2, a related factor that is normally expressed at earlier stages of hematopoiesis. Both GATA factors bind the PU.1/Sfpi1 gene at 2 highly conserved regions.