Another side of side chains | Nature Reviews Chemistry
2024年5月2日 · c, Non-symmetric stapling of native peptides involving inert β-C(sp 3)–H of serine side chain developed by Xu and co-workers 9. X and Y, natural amino acid side chains. X and …
Serine Protease, Enzyme Catalysis | Learn Science at Scitable - Nature
2010年8月24日 · Aspartic acid 102 was also close to the side chain of histidine, but on the opposite side from the serine (Figure 2) (Blow et al. 1969). Figure 2: A possible mechanism for …
inert β-C(sp 3)–H of serine side chain developed by Xu and co-workers 9. X and Y, natural amino acid side chains. S NAr, nucleophilic aromatic substitution. C, cysteine or Cys. S, serine or Ser.
of the acetyl-serine side chain which block channel to different extents, a result which may explain the dissimilar effects of aspirin on two PGHS isoforms. We also observe the product salicylic ...
Side-chain control of porosity closure in single- and multiple …
2014年2月23日 · This is larger than the 13.6% of Zn(GT) 2, but almost equivalent to that of isostructural Zn(GA) 2 (30%), despite the bulkier nature of the –CH 2 OH side chain of L …
Asc-1 Transporter (SLC7A10): Homology Models And Molecular
2020年2月28日 · The alanine-serine-cysteine transporter (referred to as SLC7A10 or Asc-1) is the light chain of the heterodimer amino acid transporter (HAT), and is a Na +-independent …
Revealing protonation states and tracking substrate in serine ...
2023年8月3日 · Serine hydroxymethyltransferase (SHMT) is a pyridoxal 5’-phosphate (PLP)-dependent enzyme and a promising drug target, however, PLP-dependent catalysis remains …
Design of activated serine–containing catalytic triads with atomic ...
2014年4月6日 · The most active design in this study, OSH55.4_1, uses a serine-histidine-histidine triad, which differs from the serine-histidine–aspartic acid/glutamic acid triads observed in …
serine side-chain may be enhanced : it may be influenced by some other side-chain (for example, histidine 1 ) in its proximity, or it may be chemically modified. One chemical modification of a ...
Tyrosine 121 moves revealing a ligandable pocket that couples
2022年4月11日 · The side-chain of Ser 83 makes a hydrogen bond (dotted red line) to the malonate and the main-chain NH of His 87 also donates a hydrogen bond to the malonate. …