SOCS2: physiological and pathological functions - PubMed
2016年1月1日 · Here, we focus on SOCS2 and review its biological function as well as its implication in pathological processes. Furthermore, we take advantage of the known crystal …
SOCS2 Gene - GeneCards | SOCS2 Protein | SOCS2 Antibody
2024年12月25日 · SOCS2 (Suppressor Of Cytokine Signaling 2) is a Protein Coding gene. Diseases associated with SOCS2 include Hematologic Cancer and Polycythemia Vera. …
Frontiers | SOCS Proteins in Immunity, Inflammatory Diseases, and ...
SOCS2 knockdown reduced growth of AML cells in vitro and delayed disease upon transplantation into mouse models, with these cells showing mature myeloid cell markers …
SOCS proteins, cytokine signalling and immune regulation
2007年5月18日 · Suppressor of cytokine signalling (SOCS) proteins are inhibitors of cytokine signalling pathways. Studies have shown that SOCS proteins are key physiological regulators …
Structural insights into substrate recognition by the SOCS2 E3 ...
The suppressor of cytokine signaling 2 (SOCS2) acts as substrate recognition subunit of a Cullin5 E3 ubiquitin ligase complex. SOCS2 binds to phosphotyrosine-modified epitopes as degrons …
The SOCS2 gene and its putative association with human ageing
2023年8月28日 · SOCS2 is a member of the suppressor of cytokine signaling (SOCS) family and is a cytokine-inducible negative regulator of cytokine receptor signaling through the JAK/STAT …
Here, we focus on SOCS2 and review its biological function as well as its implication in pathological processes. Furthermore, we take advantage of the known crystal structures of …
Loss of Socs2 improves molecular responses to IFNα in a mouse
2025年3月11日 · Here we investigated the role of Socs2, a negative regulator of cytokine signaling, in modulating the response to pegIFNα in a JAK2-V617F mouse model of MPN.
Suppressor of cytokine signaling (SOCS) 2, a protein with multiple ...
Specific studies targeting the SOCS genes in vivo have unveiled SOCS2 as the main regulator of somatic growth through regulation of GH/IGF-1 signaling. In addition, several studies indicate …
(PDF) SOCS2: physiological and pathological functions
2015年12月28日 · Here, we focus on SOCS2 and review its biological function as well as its implication in pathological processes. Furthermore, we take advantage of the known crystal …
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