SkBr3 (also known as SK-BR-3) is a human breast cancer cell line isolated by the Memorial Sloan–Kettering Cancer Center in 1970 that is used in therapeutic research, especially in context of HER2 targeting.

SK-BR-3 [SKBR3] cells were isolated from an adenocarcinoma patient treated with radiation, steroids, cytoxan, and 5-fluorouracil and can be used in breast cancer research.

Part of: ICBP43 breast cancer cell line panel. Part of: KuDOS 95 cell line panel. Part of: MD Anderson Cell Lines Project. From: Memorial Sloan Kettering Cancer Center; New York; USA. Registration: Memorial Sloan Kettering Cancer Center Office of Technology Development; SK 808. Population: Caucasian.

2022年6月27日 · Our work was aimed at exploring the cell-membrane proteome of a HER2+ breast-cancer cell line (SKBR3) to identify triggers responsible for uncontrolled cell proliferation and intrinsic resources that enable detection and therapeutic interventions.

Cell-membrane cellular subfractions of SKBR3/HER2+ breast cancer cells, used as a model system, were analyzed by high resolution mass spectrometry, and high-quality proteins (FDR<3%) identified by at least two unique peptides were …

Here, we present a dual-labeling approach for correlative light microscopy and liquid phase electron microscopy for endogenous HER2 and EGFR receptors within the plasma membranes of intact SKBR3 cells. This cell line was chosen as it widely …

The metastatic SKBR3 cell-membrane proteome revealed a broad and rich map of receptors, immune response, adhesion and transporter proteins that sustain cancer-cell interactions with the native or drug-altered tumor microenvironment.

2024年8月9日 · The proteomic analysis of SKBR3/HER2+ breast cancer cells treated with the EGFR/ERBB2 receptor Tyr kinase inhibitor Lapatinib and pan-AKT Ser/Thr kinase inhibitor Ipatasertib revealed that the drugs exerted a wide-ranging impact on signaling and biological processes that support cancer progression.

SK-BR-3 is a human breast cancer cell line that overexpresses the Her2 (Neu/ErbB-2) gene product. These cells display an epithelial morphology in tissue culture and are capable of forming poorly differentiated tumors in immunocompromised mice. The SK-BR-3 cells and products derived from it are used often as positive controls in assays for Her2.

Cell Line: SK-BR-3, Established from pleural effusion tumor cells of a 43-year-old Caucasian female patient with breast adenocarcinoma.